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  1. May 29, 2020 · CCL2-CCR2 signaling axis is implicated in many inflammatory and neurodegenerative diseases such as atherosclerosis, multiple sclerosis, asthma, neuropathic pain, diabetic nephropathy, and cancer [ 62, 63 ], and therefore is explored as a potential target for the treatment of these diseases.

    • Qiongyu Hao, Qiongyu Hao, Jaydutt V. Vadgama, Jaydutt V. Vadgama, Piwen Wang, Piwen Wang
    • 2020
  2. Nov 9, 2020 · It is now known that tumor growth, and, thus, the progression of cancer, requires communication between cancer and non-cancer cells, involving chemokines among other things. Chemokines are a group of almost 50 chemoattractant cytokines and are divided into sub-families according to the domain found at the N-terminus [ 6 , 7 ].

    • Jan Korbecki, Klaudyna Kojder, Donata Simińska, Romuald Bohatyrewicz, Izabela Gutowska, Dariusz Chlu...
    • 10.3390/ijms21218412
    • 2020
    • Int J Mol Sci. 2020 Nov; 21(21): 8412.
    • Blood Tests Also Help Determine How Chronic Lymphocytic Leukemia Will Progress.
    • When Treatment Is Needed, Blood Tests Will Continue to Play A role.
    • Learn More

    At Mayo Clinic, your care team will conduct additional blood tests to determine how quickly your disease will progress. One of these tests, fluorescence in situ hybridization (FISH), examines the chromosomes inside the cancerous lymphocytes to look for changes. Another test determines the mutation status of the immunoglobulin heavy chain (IGHV) gen...

    The testing and scoring system used to confirm the diagnosis and predict the progression of chronic lymphocytic leukemia also helps health care professionals determine the best treatment approach. "CLL is considered an indolent disease, meaning it progresses slowly. As the disease progresses, you can treat it; and people respond very well to treatm...

    Learn more about chronic lymphocytic leukemia and find a chronic lymphocytic leukemia clinical trialat Mayo clinic. Join the Blood Cancers & Disorders Support Groupon Mayo Clinic Connect. Also read "Leukemia: Cancer that affects children and adults."

  3. Jul 1, 2023 · Tumor and cancer Lung cancer. Lung cancer, which is closely concerned with CXCL family, is the most common cancer and the predominant cause of neoplasm-related deaths all over the world.

  4. Jan 6, 2023 · For example, the overexpression of CCL2 enhances the outgrowth, invasion, and metastasis of the 4T1 murine mammary cancer cell line which is one of the most widely used breast cancer models (17–19). Besides, in the nervous system, CCL2, expressed by dorsal root ganglia (DRG) under the influence of sterile alpha and Toll/interleukin-1 receptor ...

    • 10.3389/fimmu.2022.1053457
    • 2022
    • Front Immunol. 2022; 13: 1053457.
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  6. May 19, 2023 · Breast cancer is the most prevalent cancer worldwide, and metastasis is the leading cause of death in cancer patients. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was isolated from the ...

  7. Feb 18, 2022 · CXCL chemokines (CXCLs) are small cytokines or signal proteins secreted by cells that have been proven to be linked to the occurrence and development of many kinds of cancer. However, the ...

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