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   What is the mechanism of action of colchicine?

   • Searches encompassed colchicine mechanisms of action and clinical applications in medical conditions. A total of 381 articles were reviewed. The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.

   Colchicine --- update on mechanisms of action and therapeutic uses

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/

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   How does colchicine bind to microtubules?

   • The most studied therapeutic mechanism of action of colchicine is its capacity to bind to tubulins, thereby blocking the assembly and polymerization of microtubules. Microtubules, key components of the cytoskeleton, are made up of αβ-tubulin heterodimers.

   Colchicine --- update on mechanisms of action and therapeutic uses

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4656054/

   See all results for this question

   How does colchicine work in rheumatic disease?

   • Colchicine’s mechanisms of action are multiple, and more complex than previously appreciated. In rheumatic disease, colchicine is most useful for conditions driven by macrophages and neutrophils. Colchicine’s anti-inflammatory effects hold promise for prevention/management of cardiovascular conditions, including acute coronary syndromes.

   Update on colchicine, 2017 - PMC - National Center for Biotechnology

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5850858/

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   How does colchicine affect microtubule polymerization?

   • Colchicine exerts its unique action mainly through inhibition of microtubule polymerization. Microtubule polymerization affects a variety of cellular processes including maintenance of shape, signaling, division, migration, and cellular transport.

   Colchicine Pharmacokinetics and Mechanism of Action - PubMed

   pubmed.ncbi.nlm.nih.gov/29359661/

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   How does colchicine affect inflammatory response?

   • Colchicine interferes with several inflammatory pathways including adhesion and recruitment of neutrophils, superoxide production, inflammasome activation, the RhoA/Rho effector kinase (ROCK) pathway and the tumor necrosis factor alpha (TNF-α) -induced nuclear factor κΒ (NF-κΒ) pathway attenuating the inflammatory response.

   Colchicine Pharmacokinetics and Mechanism of Action - PubMed

   pubmed.ncbi.nlm.nih.gov/29359661/

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   How does colchicine affect cell migration and cytokine release?

   • This dose-dependent mechanism appears to be directly responsible, at least in vitro, for the effects of colchicine on cell migration, cytokine release and intracellular trafficking, and plays an important role in the disruption of inflammatory cell activities by colchicine [ 3 ].

   Update on colchicine, 2017 - PMC - National Center for Biotechnology

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5850858/

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2. www.ncbi.nlm.nih.gov › books › NBK431102Colchicine - StatPearls - NCBI Bookshelf

   www.ncbi.nlm.nih.gov › books › NBK431102

   May 29, 2023 · Mechanism of Action. Colchicine has primarily anti-inflammatory properties. It disrupts cytoskeletal functions by inhibiting beta-tubulin polymerization into microtubules, preventing activation, degranulation, and migration of neutrophils associated with mediating some gout symptoms.

   • Colchicine --- update on mechanisms of action and therapeutic ...

     The most studied therapeutic mechanism of action of...

   • Colchicine Pharmacokinetics and Mechanism of Action - PubMed

     Colchicine exerts its unique action mainly through...

   • Update on colchicine, 2017 - PMC - National Center for ...

     Mechanisms of action. The mechanisms through which...

3. www.ncbi.nlm.nih.gov › pmc › articlesColchicine --- update on mechanisms of action and therapeutic ...

   www.ncbi.nlm.nih.gov › pmc › articles

   The most studied therapeutic mechanism of action of colchicine is its capacity to bind to tubulins, thereby blocking the assembly and polymerization of microtubules. Microtubules, key components of the cytoskeleton, are made up of αβ-tubulin heterodimers.

   • Author: Ying Ying Leung, Ying Ying Leung, Laura Li Yao Hui, Virginia B. Kraus
   • DOI: 10.1016/j.semarthrit.2015.06.013

   • Publish Year: 2015
   • Published: 2015/12

4. go.drugbank.com › drugs › DB01394Colchicine: Uses, Interactions, Mechanism of Action ...

   go.drugbank.com › drugs › DB01394

   • Cached

   Mechanism of action. The exact mechanism of action of colchicine has not been fully established; however, colchicine likely interferes with the intracellular assembly of the inflammasome complex present in neutrophils and monocytes that mediates activation of interleukin-1β, an inflammatory mediator. 1,2,9 Colchicine also attenuates neutrophil ...

   Drug	Interaction
   Abacavir	Abacavir may decrease the excretion rate ...
   Abametapir	The serum concentration of Colchicine can ...
   Abemaciclib	The serum concentration of Abemaciclib ...
   Abrocitinib	The serum concentration of Colchicine can ...

   See full list on go.drugbank.com

5. en.wikipedia.org › wiki › ColchicineColchicine - Wikipedia

   en.wikipedia.org › wiki › Colchicine

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   Mechanism of action. In gout, inflammation in joints results from the precipitation of uric acid as needle-like crystals of monosodium urate in and around synovial fluid and soft tissues of joints.

6. pubmed.ncbi.nlm.nih.gov › 29359661Colchicine Pharmacokinetics and Mechanism of Action - PubMed

   pubmed.ncbi.nlm.nih.gov › 29359661

   Colchicine exerts its unique action mainly through inhibition of microtubule polymerization. Microtubule polymerization affects a variety of cellular processes including maintenance of shape, signaling, division, migration, and cellular transport.

   • Author: Christos Angelidis, Zoi Kotsialou, Charalampos Kossyvakis, Agathi-Rosa Vrettou, Achilleas Zacharouli...

   • Publish Year: 2018

7. www.ncbi.nlm.nih.gov › pmc › articlesUpdate on colchicine, 2017 - PMC - National Center for ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Dec 19, 2017 · Mechanisms of action. The mechanisms through which colchicine exerts its anti-inflammatory properties are multiple. Perhaps the best appreciated of these mechanisms is the ability of colchicine to bind to free tubulin dimers which, when incorporated into microtubules, block subsequent microtubule polymerization [ 2 ].

8. pubmed.ncbi.nlm.nih.gov › 26228647Colchicine--Update on mechanisms of action and therapeutic ...

   pubmed.ncbi.nlm.nih.gov › 26228647

   Results: The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.