Search results
researchgate.net
Tubulin disruption
- The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.
The primary mechanism of action of colchicine is tubulin disruption. This leads to subsequent down regulation of multiple inflammatory pathways and modulation of innate immunity.
- Ying Ying Leung, Ying Ying Leung, Laura Li Yao Hui, Virginia B. Kraus
- 10.1016/j.semarthrit.2015.06.013
- 2015
- 2015/12
People also ask
What are the anti-inflammatory mechanisms of colchicine?
Is colchicine an anti-inflammatory?
How does colchicine affect blood levels?
How does colchicine work in rheumatic disease?
Jan 19, 2022 · The predominant mechanism by which colchicine addresses CVD is through its anti-inflammatory action. The most fundamental function of colchicine is to target microtubules.
Dec 19, 2017 · Colchicine is routinely used in CPPD, for both acute flares and suppressive flare prophylaxis. Although formal evidence for its efficacy in this setting is scant, the common mechanisms of activation in urate and CPPD crystal-induced inflammation support the logic of such an approach.
- Anastasia Slobodnick, Anastasia Slobodnick, Binita Shah, Binita Shah, Svetlana Krasnokutsky, Svetlan...
- 2018
Oct 1, 2014 · Colchicine prevents microtubule assembly and thereby disrupts inflammasome activation, microtubule-based inflammatory cell chemotaxis, generation of leukotrienes and cytokines, and phagocytosis. Many of these cellular processes can be found in other diseases involving chronic inflammation.
- Nicola Dalbeth, Thomas J. Lauterio, Henry R. Wolfe
- 2014
Apr 12, 2021 · Colchicine is an anti-inflammatory agent that suppresses myeloid cell activation and is commonly used to treat gout. In this issue of Nature Metabolism, Weng et al. demonstrate that colchicine...
- Samuel M. Lockhart, Stephen O’Rahilly
- 2021
Oct 1, 2014 · Colchicine has multiple mechanisms of action that affect inflammatory processes and result in its utility for treating and preventing acute gout flare. Other chronic inflammatory diseases that invoke these molecular pathways may represent new therapeutic applications for colchicine.
The main mechanism of action of colchicine is probably through interaction with microtubules affecting leukocyte chemotaxis, thereby suppressing inflammation. The blood level of colchicine may be affected by concomitant drug administration and therefore, caution should be exercised when such medications are added.
