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- DictionaryMa·jor his·to·com·pat·i·bil·i·ty com·plex
noun
- 1. a genetic system that allows large proteins in immune system cells to identify compatible or foreign proteins. It allows the matching of potential organ or bone marrow donors with recipients.
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The major histocompatibility complex is located on chromosome 6 in humans and chromosome 17 in the mouse and extends over some 4 centimorgans of DNA, about 4 × 10 6 base pairs. In humans it contains more than 200 genes.
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Aug 31, 2023 · Learning Objectives. State which body cells display MHC-I surface molecules and which cells normally display MHC-II surface molecules. Define endogenous antigen and exogenous antigen and state which class of MHC molecule primarily binds each.
The major histocompatibility complex (MHC) is a gene cluster encoding two types of cell surface glycoprotein: class I and class II. MHC molecules were recognized early on as transplantation antigens, because they caused rejection of tissue grafts exchanged between individuals of the same species.
11.11: The Major Histocompatibility Complex (MHC) Topic hierarchy. 11.11: The Major Histocompatibility Complex (MHC) is shared under a CC BY-SA 4.0 license and was authored, remixed, and/or curated by LibreTexts.
Major histocompatibility complex (MHC) class II molecules are essential for processing and presenting exogenous pathogen antigens to activate CD4+ T cells. Given their central role in adaptive immune responses, MHC class II genes are tightly regulated in a tissue- and activation-specific manner.
