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May 27, 2018 · Pheochromocytomas and paragangliomas (PPGLs) are neuroendocrine tumors with strong genetic susceptibility, with approximately 40% harboring germline mutation. Almost 30% of the remaining sporadic cases carry a somatic mutation in a predisposition gene.
Jan 15, 2024 · Nonepithelial neuroendocrine neoplasm producing catecholamine excess and derived from neural progenitors.
Dec 1, 2015 · Definition / general. Very rare neuroendocrine tumor in lung. Usually benign. Metastases to lung are more common than a lung primary. Essential features. Classic "zellballen" / organoid pattern with S100+ sustentacular cells, similar to pheochromocytoma.
Feb 29, 2024 · Paragangliomas are rare neuroendocrine tumors arising from extra-adrenal paraganglia. While akin to pheochromocytomas, they manifest diverse symptoms contingent on their location. Typically found along the sympathetic chain, they often secrete catecholamines, causing hypertension and tachycardia.
Pheochromocytomas and extra-adrenal paragangliomas are tumors of neural crest–derived endocrine cells or organs known as paraganglia. The paraganglia occupy several anatomic locations within the body and are categorized as sympathetic or parasympathetic based on location and neural association.
Jul 2, 2019 · This book includes specific chapters written by experts from several countries that deal with relevant aspects of paraganglioma and pheochromocytoma diagnosis and therapy.
This review summarizes the classification of tumors of the adrenal medulla and extra-adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and Neuroendocrine Tumors.
The non-epithelial neuroendocrine neoplasms (NENs) known as paragangliomas produce predominantly catecholamines and secrete them into the bloodstream like hormones, and they represent a group of NENs that have exceptionally high genetic predisposition.
This review summarizes the classification of tumors of the adrenal medulla and extra-adrenal paraganglia as outlined in the 5th series of the WHO Classification of Endocrine and Neuroendocrine Tumors.
Mar 25, 2018 · Paraganglioma is a rare entity with wide age and anatomic distribution and variable cytomorphological features that often overlap with those of malignant neoplasms. Possible aggressive behavior such as recurrence and metastasis to lymph nodes, bone, and lung as well as Succinate Dehydrogenase complex mutations warrant an accurate diagnosis on ...
