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1. Dictionary

   Se·nes·cence

   /səˈnes(ə)ns/

   

   noun

   • 1. the condition or process of deterioration with age.
   • ▪ loss of a cell's power of division and growth.

   Derivatives

   • 1. senescent adjective

   Scrabble Points: 14

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2. www.merriam-webster.com › dictionary › senescenceSenescence Definition & Meaning - Merriam-Webster

   www.merriam-webster.com › dictionary › senescence

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   Senescence is the state of being old, the permanent arrest of cell division, or the growth phase in a plant from maturity to death. Learn more about the word history, synonyms, examples, and medical usage of senescence.

3. People also ask

   What is senescence in biology?

   • Senescence ( / sɪˈnɛsəns /) or biological aging is the gradual deterioration of functional characteristics in living organisms.

   Senescence - Wikipedia

   en.wikipedia.org/wiki/Senescence

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   Does senescence affect aging?

   • The largest number of study of senescence and aging processes were made on cell cultures and animal models. The senescence seems to be a critical factor in both the normal aging process and pathologies associated with aging.

   Hallmarks of senescence and aging - PMC - National Center for Biotech…

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6610675/

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   What is senescence cellular program?

   • Senescence is cellular program that induces a stable growth arrest accompanied by distinct phenotypic alterations, including chromatin remodeling, metabolic reprogramming, increased autophagy, and the implementation of a complex proinflammatory secretome ( Kuilman et al., 2010; Salama et al., 2014 ).

   Senescence and aging: Causes, consequences, and therapeutic avenues

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/

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   Why is senescence important?

   • In adult tissues, senescence is triggered primarily as a response to damage, allowing for suppression of potentially dysfunctional, transformed, or aged cells. The aberrant accumulation of senescent cells with age results in potential detrimental effects. In balance, although senescence is a biologically necessary process, it may come at a cost.

   Senescence and aging: Causes, consequences, and therapeutic avenues

   www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/

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4. en.wikipedia.org › wiki › SenescenceSenescence - Wikipedia

   en.wikipedia.org › wiki › Senescence

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   Senescence is the gradual deterioration of functional characteristics in living organisms with age. Learn about the hallmarks, evolutionary and mechanistic theories of senescence, and the variation among species and organisms.

5. Videos

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6. www.ncbi.nlm.nih.gov › pmc › articlesSenescence and aging: Causes, consequences, and therapeutic ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Jan 2, 2018 · Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. Senescence plays roles in normal development, maintains tissue homeostasis, and limits tumor progression. However, senescence has also been implicated as a major cause of age-related disease.

   • Author: Domhnall McHugh, Domhnall McHugh, Jesús Gil, Jesús Gil
   • DOI: 10.1083/jcb.201708092

   • Publish Year: 2018
   • Publication: J Cell Biol. 2018 Jan 2; 217(1): 65-77.

7. dictionary.cambridge.org › english › senescenceSENESCENCE | English meaning - Cambridge Dictionary

   dictionary.cambridge.org › english › senescence

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   Senescence is the fact of becoming older and less able to function well. Learn more about this biological term, its synonyms, and how to use it in sentences from the Cambridge English Corpus.

8. www.verywellhealth.com › senescence-healthy-agingHow Does Senescence Relate to Aging Well? - Verywell Health

   www.verywellhealth.com › senescence-healthy-aging

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   Aug 16, 2024 · Senescence is the gradual decline in health and function associated with aging. Learn about cellular senescence, organismal senescence and how to prevent or delay the effects of senescence with healthy lifestyle habits.

9. www.britannica.com › science › aging-life-processAging | Definition, Process, & Effects | Britannica

   www.britannica.com › science › aging-life-process

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   Aug 30, 2024 · Aging, progressive physiological changes in an organism that lead to senescence, or a decline of biological functions and of the organism’s ability to adapt to metabolic stress.

10. www.ncbi.nlm.nih.gov › pmc › articlesHallmarks of senescence and aging - PMC - National Center for ...

    www.ncbi.nlm.nih.gov › pmc › articles

    Oct 10, 2019 · Senescence is an irreversible form of long-term cell-cycle arrest, caused by excessive intracellular or extracellular stress or damage. The purpose of this cell-cycles arrest is to limit the proliferation of damaged cells, to eliminate accumulated harmful factors and to disable potential malignant cell transformation.