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  2. Feb 15, 2024 · 8 FDA-Approved Drugs for Weight Management. By Phuoc Anh (Anne) Nguyen, PharmD, MS, BCPS. Updated on February 15, 2024. Medically reviewed by Lindsay Cook, PharmD. Print. Table of Contents. View All. Xenical (Orlistat) Alli (Orlistat) Contrave (Bupropion-Naltrexone) Saxenda (Liraglutide) Qsymia (Phentermine-Topiramate)

    • Oral semaglutide. What it is: Oral semaglutide is a glucagon-like peptide-1 (GLP-1) agonist. It mimics the effects of GLP-1, a gut hormone that's involved in blood glucose (sugar) control, digestion, and appetite management.
    • Orforglipron. What it is: Orforglipron is an oral GLP-1 agonist. Unlike injectable GLP-1 agonists, it’s made of chemicals — not peptides (amino acid chains).
    • Danuglipron. What it is: Danuglipron is an oral GLP-1 pill. It works the same way as orforglipron. How it’s administered: Danuglipron is an oral tablet.
    • APH-012. What it is: APH-012 is an oral medicine that imitates the metabolic effects of gastric bypass (weight loss) surgery. It’s a glucose pill that’s designed to stimulate certain parts of your small intestine.
  3. Apr 1, 2024 · Prescription-only pills that are FDA approved for weight loss are summarized below. Theyre most effective when combined with lifestyle changes , such as a healthy diet and routine exercise. Keep in mind: FDA-backed weight-loss pills are highlighted in this list.

    • Phentermine (Adipex-P and Lomaira) Phentermine is one of the most widely used prescription weight loss medications in the United States and has been around since the 1950s.
    • Qsymia (Phentermine and Topiramate) This popular weight loss pill contains phentermine combined with a migraine medication called topiramate. Research shows combining these two drugs may result in greater weight loss than either alone.
    • Contrave (Naltrexone and Bupropion) Contrave is another FDA-approved prescription-only weight loss medication that combines naltrexone and bupropion.
    • Orlistat (Xenical) Orlistat is another FDA-approved prescription weight loss medication in capsule form. You may be familiar with Orlistat’s over-the-counter version, Alli, available at a lower dose.
  4. Mar 29, 2024 · Updated on March 29, 2024. When the FDA approved Wegovy (semaglutide), it became the first medication of its kind that’s specifically for weight loss. Many other weight-loss medications are in the pipeline. This may create a wide range of options that work in slightly different ways for people to choose from.

  5. Today, the U.S. Food and Drug Administration approved Wegovy (semaglutide) injection (2.4 mg once weekly) for chronic weight management in adults with obesity or overweight with at least one...

  6. Mar 28, 2022 · FDA Approval. Some diet pills are approved by the U.S. Food and Drug Administration (FDA). Others don't require FDA approval. This chart outlines what it means to have FDA approval, as well as what it means if a diet pill is not approved by the FDA. FDA-Approved Drugs. Proven to be safe.

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