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Jul 17, 2023 · Botulism is a rare, potentially fatal syndrome of diffuse, flaccid paralysis caused by botulinum neurotoxin (BoNT) which is elaborated by the bacterium Clostridium botulinum. It begins with cranial nerve paralysis which progresses down to the symmetrical weakness of the trunk and extremities with eventual flaccid paralysis.
Apr 25, 2024 · Publications on botulism epidemiology, laboratory findings, illnesses and outbreaks, food safety, and more. Search for publications and sort them by title, publication date, and category. Spotlight. Clinical Guidelines for Diagnosis and Treatment of Botulism, 2021. These are the first comprehensive clinical care guidelines for botulism.
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- Abstract
- The Organism and Its Toxins
- Botulism Syndromes and Their Epidemiology
- Clinical Presentation
- Therapeutics
- Conclusions
Botulism is a rare, naturally occurring disease that can also be caused by accidental or intentional exposure to botulinum toxins. All forms of botulism manifest essentially the same distinct clinical syndrome of symmetrical cranial nerve palsies that may be followed by descending, symmetric flaccid paralysis of voluntary muscles, which may progres...
Clostridium botulinum is ubiquitously found in soil and aquatic sediments. C. botulinum produces 7 immunologically distinct toxins, which are designated by the letters A–G. Several related clostridial species (e.g., Clostridium baratii and Clostridium butyricum) can produce some botulinum toxins as well. All produce a clinically similar, highly rec...
Foodborne botulism.Foodborne botulism is caused by consumption of foods contaminated with botulinum toxin. C. botulinum grows and elaborates toxin only when the food presents conditions that include an anaerobic milieu, a pH of <4.5, low salt and sugar content, and a temperature of 4°C–121°C . Home-canned foods have long constituted a major source ...
The clinical syndrome of botulism is highly distinctive, consisting of symmetrical cranial nerve palsies, followed by symmetrical descending flaccid paralysis that may progress to respiratory arrest [19, 35]. For a sporadic (isolated) case, the differential diagnosis is not extensive, and the combination of neurological findings and specific labora...
Supportive intensive care.During the first decades of the 20th century in the United States, the mortality rate among patients with botulism was 60%–70%, even when equine antitoxin was administered in heroic doses. During the late 1940s and 1950s, the mortality rate decreased precipitously, until it reached the current rate of 3%–5% . The differenc...
Regardless of the mode of exposure, botulinum toxins produce a distinctive syndrome of cranial nerve palsies that may be followed by descending flaccid paralysis. Effective treatment depends on provision of intensive care and rapid administration of botulinum antitoxin based on clinical presentation, because laboratory diagnosis is time-consuming. ...
May 5, 2021 · Background. These evidence-based guidelines provide health care personnel with recommended best practices for diagnosing, monitoring, and treating botulism in the settings of conventional, contingency, and crisis standards of care.
- Agam K. Rao, Jeremy Sobel, Kevin Chatham-Stephens, Carolina Luquez
- 2021
46 Citations. 1 Altmetric. Abstract. Botulism is a very serious foodborne illness, often fatal, and characterized by neuroparalytic signs and symptoms. Early observations found an association with consumption of sausages, and thus the name botulism (derived from botulus, Latin for sausage) was given to the disease ( Smith and Sugiyama 1988).
Jan 1, 2009 · Download book EPUB. Bacterial Infections of Humans. Patricia A Yu, Susan E Maslanka, Michael E St Louis & David L Swerdlow. 2974 Accesses. 5 Citations. Botulism is a neuroparalytic illness resulting from the action of a potent toxin produced by the organism Clostridium botulinum.
