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Nobel Prize in Science. César Milstein was awarded the 1984 Nobel Prize in Physiology or Medicine jointly with his former postdoctoral fellow Georges J. F. Köhler (AAI '85) and theoretician Niels Jerne (AAI '73). Milstein and Köhler won the prize for developing the hybridoma method of producing monoclonal antibodies.
Jun 1, 2002 · Their invention sprang from basic research on antibody diversity and specificity, and spawned revolutionary advances in biology, medicine and industry. Celia and César Milstein, with Tim and...
- Timothy A. Springer
- 2002
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May 17, 2002 · Milstein and I made the first monoclonal antibodies to cell adhesion molecules. In collaboration with Claudio Cuello, he worked on the immunocytochemistry of the nervous system, and with Herman Waldmann on making antibodies to human hematopoietic cell antigens.
- Timothy A. Springer
- 2002
Milstein's father, Lazaro, was born in a village in the Ukraine and migrated to Argentina in 1913 at the age of 14 with his aged aunt and uncle. For many years he lived in Jewish settlements near Bahía Blanca trying his hand at different trades, including farm labour, carpentry and railway work. During this time he taught himself Spanish and ...
Brenner and Milstein enjoyed referring to this postulated mechanism as the ' generator of diversity ' (GOD). Milstein explored his hypothesis by shifting attention from the structure of antibody proteins to the genes (DNA) that code
Apr 30, 2002 · César Milstein, who died on 24 March, spent the major part of his research career working on antibodies, making outstanding contributions to both areas. Behring's discovery was recognised by the award in 1901 of the first Nobel Prize in Physiology or Medicine. Milstein and Köhler's discovery of monoclonal antibodies was recognised in the 1984 ...
Apr 25, 2002 · César Milstein began to study antibody diversity at a time when almost nothing was known about its molecular and genetic basis. As a logical step in that work, with Georges Köhler he devised...
