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  1. Von Willebrand disease is the most common inherited bleeding disorder among American women, with a prevalence of 0.6–1.3% 1. The overall prevalence is even greater among women with chronic heavy menstrual bleeding, and ranges from 5% to 24% 2 3. Among women with heavy menstrual bleeding, von Willebrand disease appears to be more prevalent ...

  2. General guidelines for the treatment of women with von Willebrand disease at delivery. Since pregnant women with VWD are at increased risk of postpartum hemorrhage if untreated 9, 17, 27, 31, treatment options should be planned at the beginning of pregnancy.

    • Giancarlo Castaman, Paula D. James
    • 10.1111/ejh.13250
    • 2019
    • 2019/08
  3. May 15, 2024 · With proper care, women with von Willebrand disease (VWD) can have a successful pregnancy and deliver a healthy child. Close monitoring throughout pregnancy is important for women with VWD. Women with VWD are at risk for serious bleeding after delivery.

  4. Reynen E, James P. Von Willebrand disease and pregnancy: a review of evidence and expert opinion. Semin Thromb Hemost . 2016;42(7):717-723. Stoof SC, van Steenbergen HW, Zwagemaker A, et al. Primary postpartum haemorrhage in women with von Willebrand disease or carriership of haemophilia despite specialised care: a retrospective survey.

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  6. May 20, 2019 · The variable pattern of changes observed during pregnancy of von Willebrand factor (VWF) and factor VIII (FVIII), the protein carried by VWF, prompts a careful evaluation of pregnant women with VWD to plan the most appropriate treatment at the time of parturition.

    • Giancarlo Castaman, Paula D. James
    • 2019
  7. Jan 1, 2022 · Introduction. Von Willebrand disease (VWD) is a common bleeding disorder that typically manifests with mucosal bleeding. 1 Although women and men are equally likely to be affected, women with VWD are more likely to have bleeding symptoms related to the high prevalence of heavy menstrual bleeding (HMB).

  8. Apr 26, 2010 · Bleeding complications during pregnancy are more frequent when levels of the von Willebrand ristocetin cofactor assay and factor VIII levels are <50 IU/dL. von Willebrand disease and pregnancy: a practical approach for the diagnosis and treatment - American Journal of Obstetrics & Gynecology

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