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Dec 6, 2019 · Review preoperative risk assessment strategies to guide hemostatic cover at the time of surgery for people with von Willebrand disease. Understand the distinctions between differing von Willebrand factor replacement therapies and the timing of administration preoperatively
- James S. O’Donnell, Michelle Lavin
- 2019
Jan 12, 2021 · Major therapies include use of desmopressin to induce endothelial release of stored von Willebrand factor (VWF) and factor VIII (FVIII) and use of VWF concentrates, including both plasma-derived and recombinant products, as well as adjuvant therapies, such as antifibrinolytic tranexamic acid.
- Nathan T. Connell, Veronica H. Flood, Romina Brignardello-Petersen, Rezan Abdul-Kadir, Alice Arapshi...
- 2021
Jun 4, 2020 · This review provides an overview of the current evidence for the surgical management of patients with VWD and, summarises the optimal treatment approach during the perioperative period, and highlights key unanswered questions and the research needed to address the evidence gaps.
- Wolfgang Miesbach
- 2020
Oct 26, 2021 · Many doctors consider desmopressin (DDAVP) the first treatment for managing von Willebrand disease. It can be used before minor surgical procedures to help control bleeding. You might be given a trial of desmopressin to make sure it's effective for you.
Jan 1, 2022 · Treatment options for patients with VWD who are undergoing surgery include administration of VWF-containing concentrates (both plasma derived and recombinant), desmopressin to induce release of stored endogenous VWF from the vascular endothelium, and adjunctive antifibrinolytic therapy such as tranexamic acid (TXA). 4.
- 10.1182/bloodadvances.2021005666
- 2022/01/01
- Blood Adv. 2022 Jan 11; 6(1): 121-128.
Apr 16, 2024 · Approach to the adult with a suspected bleeding disorder. Pathophysiology of von Willebrand disease. Clinical presentation and diagnosis of von Willebrand disease. von Willebrand disease (VWD): Treatment of major bleeding and major surgery.
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Can von Willebrand disease be cured?
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What is von Willebrand disease (vWD)?
Dec 22, 2021 · Unlike patients with severe hemophilia, most patients with VWD generally have less frequent and clinically severe bleeding, so that they usually receive treatment episodically at the time of bleeding, in anticipation of invasive procedures, at menstruation, during and after labor, or after trauma.
