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- Among the cells found in the tumour environment, adipocytes from adipose tissue establish a vicious cycle with cancer cells to promote cancer survival, proliferation, metastasis and treatment resistance. This cycle is particularly of interest in the context of obesity, which has been found as a cancer risk factor.
pubmed.ncbi.nlm.nih.gov › 33009650Interaction between adipose tissue and cancer cells: role for ...
May 14, 2024 · Here, we aim to investigate the formation of cancer-associated adipocytes (CAAs) and their contribution to tumor growth using mouse models harboring dysfunctional adipocytes.
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Aug 31, 2023 · In summary, we show that, in an adipose-rich tumor microenvironment, cancer cells generate G3P as a precursor for critical membrane and signaling components, thereby promoting metastasis.
- Abir Mukherjee
Sep 10, 2019 · A better understanding of cancer-associated adipocytes and the key molecular events in the adipocyte-cancer cell crosstalk will provide insights into tumor biology and permit the optimization of therapeutic strategies.
- Qi Wu, Qi Wu, Qi Wu, Bei Li, Zhiyu Li, Juanjuan Li, Si Sun, Shengrong Sun
- 2019
Searches related to adipose cells adipocytes and cancer growth
Jun 1, 2023 · Adipose-derived exosomes have been shown to stimulate the proliferation and metastasis of breast cancer cells. Adipocytes in the obese state were also shown to stimulate the expression of the ER, as well as the growth, motility, and invasion of triple-negative breast cancer cells by activating HIF1α.
Adipose tissue influences tumor development in two major ways. First, obese individuals have a higher risk of developing certain cancers (endometrial, esophageal, and renal cell cancer). However, the risk of developing other cancers (melanoma, rectal, and ovarian) is not altered by body mass.
- Kristin M. Nieman, Iris L. Romero, Bennett Van Houten, Ernst Lengyel
- 2013
Over the last decade, it became clear that tumor cells co-opt adipocytes in the tumor microenvironment, converting them into cancer-associated adipocytes (CAA). As adipocytes and cancer cells engage, a metabolic symbiosis ensues that is driven by bi-directional signaling.
Jan 7, 2021 · Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals.
