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Androgen insensitivity syndrome (AIS) occurs when someone is genetically male but is insensitive to androgens (male sex hormones). This means the person has male sex chromosomes (one X and one Y chromosome) but may have female genitals. AIS is a disorder of sex differentiation.
Jan 16, 2023 · Androgen insensitivity syndrome (AIS) is an intersex condition in which people who are genetically male experience variations in their sexual and reproductive organs.
- AIS is an inherited condition that results from androgen receptor gene mutations. These genetic mutations prevent the body from using androgen horm...
- It's extremely common for people with AIS to experience fertility concerns. However, these concerns can result from different causes, depending on...
- Sex hormones play an important role in the human body, both reproductively and nonreproductively. As a result, all humans naturally produce both an...
- "Intersex" is a term used to describe a person who is born with variations in their reproductive or sexual anatomy. Sometimes, this can look like c...
Oct 24, 2023 · The initial diagnosis of androgen insensitivity is usually because of symptoms. Often, complete androgen insensitivity is not diagnosed until puberty. Lack of menstruation blood in combination with normal breast growth and a lack of pubic and underarm hair should cause doctors to suspect CAIS.
The AR protein (pictured) mediates the effects of androgens in the human body. Androgen insensitivity syndrome (AIS) is a condition involving the inability to respond to androgens, typically due to androgen receptor dysfunction. [1] It affects 1 in 20,000 to 64,000 XY (karyotypically male) births.
Mar 24, 1999 · Androgen insensitivity syndrome (AIS) is typically characterized by evidence of feminization (i.e., undermasculinization) of the external genitalia at birth, abnormal secondary sexual development in puberty, and infertility in individuals with a 46,XY karyotype.
- Bruce Gottlieb, Bruce Gottlieb, Mark A Trifiro, Mark A Trifiro
- 2017/05/11
- 2014
3 days ago · Androgen insensitivity syndrome (AIS), formerly known as testicular feminization, is an X-linked recessive condition resulting in a failure of normal masculinization of the external genitalia...
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Androgen insensitivity syndrome is a genetic condition which affects a child’s sexual development before birth and during puberty. Learn about the signs and symptoms of androgen insensitivity syndrome, what causes it, and how it's diagnosed and treated at CHOP.
