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Cell-surface protein
- Colony stimulating factor 1 receptor (CSF1R), also known as macrophage colony-stimulating factor receptor (M-CSFR), and CD115 (Cluster of Differentiation 115), is a cell-surface protein encoded by the human CSF1R gene (known also as c-FMS).
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What are colony-stimulating factors (CSFs)?
What ligands activate CSF1R?
CSF1R is a receptor that can be activated by two ligands: colony stimulating factor 1 (CSF-1) and interleukin-34 (IL-34). CSF1R is highly expressed in myeloid cells, and CSF1R signaling is necessary for the survival, proliferation, and differentiation of many myeloid cell types in vivo and in vitro.
Colony-stimulating factor. Colony-stimulating factors ( CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of committed progenitors [1] in the bone marrow, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white ...
Colony stimulating factor 1 receptor (CSF1R) is a class III receptor tyrosine kinase that is expressed on the cell surface of microglia and macrophages. 111 CSF1R is directly involved in controlling development, survival and maintenance of microglia and these effects are associated with neuroinflammation. 112 For instance in transgenic AD mice ...
Jan 24, 2024 · Colony-Stimulating Factor 1 Receptor (CSF1R) is a transmembrane receptor tyrosine kinase (RTK) that is activated by two cognate cytokines, Colony-Stimulating Factor-1 (CSF-1) and Interleukin-34 (IL-34) [1, 2].
Dec 7, 2021 · The Colony Stimulating Factor-1 Receptor (CSF-1R)-Mediated Regulation of Microglia/Macrophages as a Target for Neurological Disorders (Glioma, Stroke) - PMC. Journal List. Front Immunol. PMC8688767. As a library, NLM provides access to scientific literature.
- 10.3389/fimmu.2021.787307
- 2021
- Front Immunol. 2021; 12: 787307.
Abstract. Macrophages are found in all tissues and regulate tissue morphogenesis during development through trophic and scavenger functions. The colony stimulating factor-1 (CSF-1) receptor (CSF-1R) is the major regulator of tissue macrophage development and maintenance.
SCF is structurally unrelated to VEGF and possesses a different dimerization mode, as SCF monomers form head-to-head dimers, in contrast to the side-by-side arrangement within PDGF or VEGF dimers ( Figure 42.3 ). As a consequence, these cytokine dimers engage their receptors in different manners.
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