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  1. my.clevelandclinic.org · health · diseasesStiff Person Syndrome (SPS): What It Is, Symptoms & Treatment

    Stiff person syndrome (SPS) is a rare autoimmune neurological disorder that causes muscle stiffness in your trunk and abdomen (the middle part of your body). Over time, you may also develop stiffness (rigidity) and spasms in your legs and other muscles. Walking may be difficult, and you may become more prone to falls and injury.

  2. www.hopkinsmedicine.org · health · conditions-andStiff Person Syndrome (SPS) - Johns Hopkins Medicine

    Stiff person syndrome is a rare autoimmune neurological disorder that most commonly causes muscle stiffness and painful spasms that come and go and can worsen over time. However, some people experience other symptoms such as an unsteady gait, double vision or slurred speech. SPS symptoms are thought to be related to which type of SPS a person ...

  3. www.webmd.com · brain · what-to-know-about-stiffSymptoms, Causes, and Treatment of Stiff Person Syndrome - WebMD

    Because of its symptoms, SPS is often misdiagnosed as: Multiple sclerosis. Parkinson’s disease. Fibromyalgia. Psychosomatic illness. Muscular dystrophy. Anxiety. Phobia. To obtain a diagnosis ...

  4. www.verywellhealth.com · stiff-person-syndrome-8387228Stiff Person Syndrome: Triggers and Treating Symptoms

    Nov 17, 2023 · The symptoms of stiff person syndrome are expected to worsen over time gradually. The effects of stiff person syndrome occur due to muscle stiffness and muscle spasms, described as follows: Muscle stiffness: The muscle stiffness of stiff person syndrome can feel like the muscles are tight, sore, and difficult to move—but they are not ...

  5. www.yalemedicine.org · conditions · stiff-personStiff Person Syndrome (SPS) > Fact Sheets - Yale Medicine

    The main symptoms of Stiff Person Syndrome are muscle stiffening in the torso and limbs, along with episodes of violent muscle spasms. These can be triggered by environmental stimuli (like loud noises) or emotional stress. The muscle spasms can be so severe that they cause the person to fall down. The muscles gradually relax after the stimulus ...

  6. www.ncbi.nlm.nih.gov · pmc · articlesStiff-Person Syndrome: A Treatment Update and New Directions

    Dec 9, 2020 · Abstract. Stiff-person syndrome (SPS) is a rare and disabling central nervous system disorder with no satisfactory treatment. Muscle rigidity, sporadic muscle spasms, and chronic muscle pain characterize SPS. SPS is strongly correlated with autoimmune diseases, and it is usual to find high titers of antibodies against acid decarboxylase (GAD65).

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  8. www.ninds.nih.gov · stiff-person-syndromeStiff-Person Syndrome | National Institute of Neurological ...

    Jul 19, 2024 · Stiff-person syndrome (SPS) is a rare, progressive neurological disorder. Symptoms may include: Stiff muscles in the trunk (torso), arms, and legs. Greater sensitivity to noise, touch, and emotional distress, which can set off muscle spasms. Over time people with SPS may develop hunched over postures. Some people may be too disabled to walk or ...