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In resectable GIST, treatment is multimodal. For tumors with a high risk of recurrence, as deter mined by tumor size and mitotic rate, adjuvant therapy with imatinib is indicated. In metastatic disease, systemic drug therapy is the treatment of choice.
The introduction of tyrosine kinase inhibitors targeting these receptors has substantially improved the outcomes in this formerly chemoresistant cancer. As of today, five agents hold regulatory approval for the treatment of GIST: imatinib, sunitinib, regorafenib, ripretinib, and avapritinib.
Treatments for GIST. Unlike other types of cancer, GISTs cannot be treated effectively with standard chemotherapy or radiation.
These NCCN Guidelines for Patients are based on the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Gastrointestinal Stromal Tumors, Version 1.2023 – March 13, 2023. View the NCCN Guidelines for Patients free online.
Aug 20, 2018 · The approaches to treating GISTs are to resect primary low-risk tumors, resect high-risk primary or metastatic tumors with imatinib 400 mg daily for 12 months, or if the tumor is unresectable, neoadjuvant imatinib 400 mg daily followed by surgical resection is recommended.
- Trisha M. Parab, Michael J. DeRogatis, Alexander M. Boaz, Salvatore A. Grasso, Paul S. Issack, David...
- 10.21037/jgo.2018.08.20
- 2018
- 2019/02
Jul 7, 2018 · Gastrointestinal stromal tumors (GISTs) are the most common malignant subepithelial lesions (SELs) of the gastrointestinal tract. They originate from the interstitial cells of Cajal located within the muscle layer and are characterized by over-expression of the tyrosine kinase receptor KIT.
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What is a gastrointestinal stromal tumor (GIST)?
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Gastrointestinal stromal tumours (GISTs) are malignant mesenchymal tumours with a variable clinical behaviour, marked by differentiation towards the interstitial cells of Cajal.1 GISTs belong to the family of soft tissue sarcomas (STSs) but are treated separately due to their peculiar histogenesis, clinical behaviour and specific therapy.
