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  1. www.ahajournals.org · doi · 10Nitrate Therapy | Circulation - AHA/ASA Journals

    May 17, 2011 · In the setting of coronary artery disease, nitrate tolerance has been demonstrated as the loss of effects on treadmill walking time and time of onset of angina.

  2. www.mayoclinicproceedings.org · article · S0025-6196Use of Nitrates and Risk of Cardiovascular Events in Patients ...

    This study aimed to investigate whether nitrate use increased the risk of cardiovascular events in patients with HFpEF. The present study is not a prespecified secondary analysis of the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial data.

    • Tetsuro Tsujimoto, Hiroshi Kajio
    • 2019

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  4. www.ajconline.org · article · S0002-9149(97)00998-3Clinical Mechanisms of Nitrate Action - American Journal of ...

    Jan 8, 1998 · Nitrates are a cornerstone in the therapy of coronary artery disease and congestive heart failure. Through the years, their utility in the management of angina of effort, unstable angina, acute and chronic heart failure, and acute myocardial infarction has become well recognized.

  5. link.springer.com · article · 10Challenges with Nitrate Therapy and Nitrate Tolerance ...

    Mar 25, 2014 · Nitroglycerin and long-acting organic nitrates are among the oldest remedies used in the management of patients with ischemic heart disease, acute left ventricular (LV) heart failure, chronic heart failure due to reduced systolic LV function, and acute hypertensive crisis [1].

    • Udho Thadani
    • udho-thadani@ouhsc.edu
    • 2014

  6. www.jacc.org · doi · 10Nitrate Therapy for Heart Failure: Benefits and Strategies to ...

    In patients with coronary disease, two studies have shown that ACE inhibitors prevent tolerance after 24 to 48 h of continuous nitroglycerin use, with an increase in cardiac index and reductions in systemic vascular resistance, arterial pressure, and pulmonary wedge pressure (18,55).

    • Divya Gupta, Vasiliki V. Georgiopoulou, Andreas P. Kalogeropoulos, Catherine N. Marti, Clyde W. Yanc...
    • 2013

  7. www.ahajournals.org · doi · fullAssociation Between Use of Long-Acting Nitrates and Outcomes ...

    Apr 4, 2017 · Nitrates may be beneficial in heart failure with preserved ejection fraction (HFpEF) by enhancing cGMP signaling and improving hemodynamics, but real-world data on potential efficacy are lacking.

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  9. www.aafp.org · pubs · afpStable Coronary Artery Disease: Treatment | AAFP

    Mar 15, 2018 · Patients with angina whose symptoms are not controlled with beta blockers or calcium channel blockers can use long-acting nitrates; short-acting nitrates can be used for quick relief of...

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