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Exogenous nitrate therapy has beneficial effects for HF treatment at the cellular and hemodynamic level by enhancing endothelium dependent vasodilation and improving systolic function and exercise capacity and inhibiting cardiac remodeling in black and non-black HF patients (8,12,13,17–19).
- Divya Gupta, Vasiliki V. Georgiopoulou, Andreas P. Kalogeropoulos, Catherine N. Marti, Clyde W. Yanc...
- 2013
May 17, 2011 · In the setting of coronary artery disease, nitrate tolerance has been demonstrated as the loss of effects on treadmill walking time and time of onset of angina.
Searches related to define major glass defect in heart disease treatment nitrate therapy
This study aimed to investigate whether nitrate use increased the risk of cardiovascular events in patients with HFpEF. The present study is not a prespecified secondary analysis of the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial data.
- Tetsuro Tsujimoto, Hiroshi Kajio
- 2019
www.ncbi.nlm.nih.gov · pmc · articlesNitrates as an Integral Part of Optimal Medical Therapy and ...
Apr 23, 2012 · The use of short‐ and rapidly‐acting nitrates (eg, sublingual nitroglycerin spray and tablets) is at the core of the therapeutic armamentarium and should be integrated into optimal medical therapy for stable angina along with exercise therapy.
- William E. Boden, Aloke V. Finn, Dharmesh Patel, W. Frank Peacock, Udho Thadani, Franklin H. Zimmerm...
- 10.1002/clc.21993
- 2012
- Clin Cardiol. 2012 May; 35(5): 263-271.
Oct 10, 2015 · Organic nitrates, such as nitroglycerin (GTN), isosorbide-5-mononitrate and isosorbide dinitrate, and pentaerithrityl tetranitrate (PETN), when given acutely, have potent vasodilator effects improving symptoms in patients with acute and chronic congestive heart failure, stable coronary artery disease, acute coronary syndromes, or arterial ...
- Andreas Daiber, Thomas Münzel
- 10.1089/ars.2015.6376
- 2015
- 2015/10/10
www.uptodate.com · contents · nitrates-in-theNitrates in the management of chronic coronary syndrome
Oct 17, 2023 · In patients with exertional stable angina, nitrates improve exercise tolerance, time to onset of angina, and ST-segment depression during exercise testing. In combination with beta blockers or calcium channel blockers, nitrates produce greater antianginal and antiischemic effects.
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How effective is nitrate therapy for ischemic heart disease?
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Is long-term nitrate use deleterious in ischemic heart disease?
Mar 25, 2014 · Nitroglycerin and long-acting organic nitrates are among the oldest remedies used in the management of patients with ischemic heart disease, acute left ventricular (LV) heart failure, chronic heart failure due to reduced systolic LV function, and acute hypertensive crisis [1].
