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Winner cells do not need draper, wasp, or psr to kill loser cells ; Hemocytes are required for removal of the resulting apoptotic debris
- Fidel-Nicolás Lolo, Sergio Casas-Tintó, Eduardo Moreno
- 2012
May 14, 2020 · Human breast and colon cancer cells highly express a winner form of FWE, whereas neighboring stromal cells express loser forms of FWE at high levels. Loss of winner FWE isoforms in the cancer cells reduced tumor growth when injected into a host mouse as part of a xenograft model.
- Wonho Kim, Rajan Jain
- 2020
Jul 1, 2020 · The molecular mechanisms through which winner cells sense loser cells, and vice versa, is an intense area of research. As discussed earlier, two factors involved in cell competition are ribosomal proteins, essential for growth, and Myc, an evolutionarily conserved activator of cell growth.
- Wonho Kim, Rajan Jain
- 2020
Jul 5, 2019 · In the context of cell competition less-fit cells can be termed as ‘loser’ cells, whereas more-fit cells can be considered to be ‘winner’ cells. The second step of cell competition involves the loser cells being eliminated from the tissue.
- Sarah Bowling, Katerina Lawlor, Tristan A. Rodríguez
- 2019
Viable cells with reduced fitness are often eliminated by neighboring cells with greater fitness. This phenomenon, called cell competition, is an important mechanism for maintaining a high-quality population of cells in tissues.
According to this idea, competent winner cells not only extrude loser cells from the microenvironment, but also actively engulf apoptotic debris, thereby winners overproliferate to compensate for cell loss and subsequently give rise to more aggressive cancers.
People also ask
What is the difference between 'loser' and 'winner' cells in cell competition?
How do winner cells sense loser cells?
Can determinants of cell competition induce 'winner' cells to 'loser' cells?
Do WT cells induce the death of 'loser cells'?
Jul 5, 2019 · The process of cell competition results in the 'elimination of cells that are viable but less fit than surrounding cells'. Given the highly heterogeneous nature of our tissues, it seems increasingly likely that cells are engaged in a 'survival of the fittest' battle throughout life.
