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      • An increase in core body temperature is known to improve survival and resolve infections. While an increased body temperature subsequently leads to an increased metabolic cost, it is known that the survival benefits outweigh the metabolic cost associated with a fever.
      www.ncbi.nlm.nih.gov › books › NBK562334
  1. Fever is a cardinal response to infection that has been conserved in warm and cold-blooded vertebrates for over 600 million years of evolution. The fever response is executed by integrated physiological and neuronal circuitry and confers a survival benefit during infection.

    • Sharon S Evans, Elizabeth A Repasky, Daniel T Fisher
    • 10.1038/nri3843
    • 2015
    • 2015/06
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  3. Nov 23, 2020 · Observational trials in humans suggest a survival benefit from fever, and randomized trials published before COVID-19 do not support fever reduction in patients with infection. Like public health measures that seem burdensome and excessive, fevers involve costly trade-offs but they can prevent infection from getting out of control.

    • Sylwia Wrotek, Edmund K LeGrand, Artur Dzialuk, Joe Alcock
    • 10.1093/emph/eoaa044
    • 2021
    • Evol Med Public Health. 2021; 9(1): 26-35.
  4. Sep 4, 2023 · The fever response is a systemic reaction to an infection that has evolved in warm-blooded animals for over 600 million years. An increase in core body temperature is known to improve survival and resolve infections.

    • 2023/09/04
  5. Sep 11, 2023 · Fevers ability to control infections comes from the few extra, but critical, degrees it adds to enhance existing locally generated heat to harm vulnerable growing pathogens. And fever also ...

  6. May 15, 2015 · There is mounting evidence that the increase in core body temperature of 1 °C to 4 °C that occurs during fever is associated with improved survival and the resolution of many...

    • Sharon S Evans, Elizabeth A Repasky, Daniel T Fisher
    • 2015
  7. Mar 15, 2022 · Fever: How it stimulates the immune system. Why fever can be your friend in times of illness. Researchers claim that fevers are more than just a symptom of illness or infection. They found that...

  8. Key Points. Fever is an elevated body temperature that occurs when the body's thermostat (located in the hypothalamus) resets at a higher temperature, primarily in response to an infection. Elevated body temperature that is not caused by a resetting of the temperature set point is called hyperthermia. Normal body temperature varies by.

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