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  1. May 1, 2012 · The challenges for clinicians are threefold: (1) identifying neonates with a high likelihood of sepsis promptly and initiating antimicrobial therapy; (2) distinguishing “high-risk” healthy-appearing infants or infants with clinical signs who do not require treatment; and (3) discontinuing antimicrobial therapy once sepsis is deemed unlikely.

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  3. Sep 29, 2022 · Neonatal sepsis is divided into 2 groups based on the time of presentation after birth: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis in neonates at or before 72 hours of life (some experts use 7 days), and LOS is defined as sepsis occurring at or after 72 hours of life [2].

    • Meenakshi Singh, Mahdi Alsaleem, Cory P. Gray
    • 2022/09/29
  4. Babies who are 34+0 to 34+6/7 weeks GA who had maternal cervical incompetence, preterm labor, PROM, clinical concern for IAI (intra-amniotic infection), or acute onset of unexplained non-reassuring fetal status are at highest risk for EOS.

  5. Jan 1, 2023 · Risk factors for sepsis include birth to mothers with inadequately treated maternal group B Streptococcus colonization, intra-amniotic infection, maternal temperature greater than 100.4°F (>38°C), rupture of membranes greater than 18 hours, and preterm labor.

  6. Dec 1, 2018 · Our purpose in this clinical report is to provide a summary of the current epidemiology of neonatal sepsis among infants born at ≥35 0/7 weeks’ gestation and a framework for the development of evidence-based approaches to sepsis risk assessment among these infants.

    • Karen M. Puopolo, Karen M. Puopolo, William E. Benitz, Theoklis E. Zaoutis, Newborn
    • 2018
  7. Neonatal Early Onset Sepsis (EOS) Care Guideline Considerations • Risk factors for EOS include: prematurity, history of prolonged rupture of membranes (> 18 hrs); inadequate GBS intrapartum antibiotic prophylaxis for the mother; history of maternal fever during labor • Consider viral etiology if the patient does

  8. May 22, 2024 · Key points. CDC conducts active surveillance for early-onset neonatal sepsis. Early-onset neonatal sepsis is a serious bloodstream infection in infants in the first days of life. Group B Streptococcus (GBS) and Escherichia coli ( E. coli) bacteria are leading causes of early-onset neonatal sepsis.

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