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- The follicles are lined with follicular cells and are filled with a fluid known as colloid that contains the prohormone thyroglobulin. The follicular cells contain the enzymes needed to synthesize thyroglobulin, as well as the enzymes needed to release thyroid hormone from thyroglobulin.
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Jan 14, 2022 · Thyroid hormones are crucial for brain development, and influence brain function throughout life. In adults, hypothyroidism causes lethargy, hyporeflexia, and poor motor coordination ( 1, 2 ), is associated with bipolar affective disorders, depression, or loss of cognitive functions ( 3, 4 ).
- Fig. 4
Thyroid hormone transport and metabolism in the rodent...
- Physiology, Thyroid
When TSH stimulates the thyroid follicle, thyroid peroxidase...
- Fig. 4
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Feb 13, 2023 · When TSH stimulates the thyroid follicle, thyroid peroxidase then organifies or covalently bonds the tyrosine of the thyroglobulin molecule within to colloid to iodine. If one iodine covalently bonds to tyrosine on the thyroglobulin, this forms monoiodotyrosine (MIT).
- 2023/02/13
Thyroid hormone (TH) is essential for normal brain development and may also promote recovery and neuronal regeneration after brain injury. TH acts predominantly through the nuclear receptors, TH receptor alpha (THRA) and beta (THRB).
- Yan-Yun Liu, Gregory A. Brent
- 10.1016/j.pharmthera.2018.01.007
- 2018
- 2018/06
Jan 9, 2024 · Thyroid hormones are critical determinants of brain and somatic development in infants and of metabolic activity in adults; they also affect the function of virtually every organ system. Thyroid hormones must be constantly available to perform these functions.
In the colloid, peroxidase enzymes link the iodine to the tyrosine amino acids in thyroglobulin to produce two intermediaries: a tyrosine attached to one iodine and a tyrosine attached to two iodines.
- Lindsay M. Biga, Sierra Dawson, Amy Harwell, Robin Hopkins, Joel Kaufmann, Mike LeMaster, Philip Mat...
- 2019
Jul 30, 2022 · The accumulation of colloid increases the overall size of the thyroid gland, a condition called a goiter (Figure 3). A goiter is only a visible indication of the deficiency. Other iodine deficiency disorders include impaired growth and development, decreased fertility, and prenatal and infant death.
Apr 21, 2022 · Thyroid hormones regulate many physiological functions such as thermogenesis, reproduction, female ovarian cycle, and lactation. They are also crucial for regulating appropriate brain growth in infants and metabolic functions in adults, in addition to a broad array of functions on each organ and system.