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Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow.
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Idiosyncratic drug reactions are a significant cause of...
- Drug Antigenicity, Immunogenicity and Co-Stimulatory Signalling
Introduction. Hypersensitivity represents one of the most...
- Granulysin Activates Antigen-Presenting Cells Through TLR4 and Acts as an Immune Alarmin
Introduction. The granulysin (GNLY) gene is located on...
- Fig. 3
Feb 9, 2020 · Abstract. Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that can vary by drug and patient. The complex and unpredictable nature of IADRs combined with the fact that they are rare makes them particularly difficult to predict, diagnose, and treat.
- Merrie Mosedale, Paul B Watkins
- 2020
- Pharmacological Definition of Idiosyncrasy
- Pathophysiology of Idiosyncratic Drug Reactions
- Classical Examples of Drug-Induced Idiosyncratic Reactions
The definition from Textbook of Pharmacologyby Seth is: That's probably as good as it gets. It is impossible to give a clear official definition for exam purposes because the term, as Uetrecht and Nasibitt put it, "has been used in various ways and has no clear definition". These authors decided to describe it as That is quite different from Goodma...
Idiosyncratic reactions are generally thought to be immune-mediated. There is no agreement on their precise mechanism, and there are many exceptions to contradict every hypothesis. In summary: 1. Either the drug itself, or a reactive metabolite, binds to a protein 2. That protein undergoes a chemical and morphological change, breaking self-toleranc...
There is the distinct possibility that some cruel viva scenario will call for the sweating exam candidate to produce a list of idiosyncratic drug reactions as examples. A solid offering from the literature is hard to find. Here is a short list which was generated by combing through the article by Knowles et al (2000) and Park et al (1992)
Oct 30, 2023 · The great majority of hypersensitivity reactions are mediated by immunologic and/or inflammatory mechanism. In addition, there are reactions, referred to as idiosyncratic drug reactions and exaggerated sensitivity reactions, which present with symptoms that do not involve the immune system or inflammatory cells.
There are three principal hypotheses for how reactive metabolites might induce an immune-mediated idiosyncratic reaction: the hapten hypothesis, the danger hypothesis, and the PI hypothesis. It has been proposed that some idiosyncratic reactions, especially those involving the liver, represent metabolic idiosyncrasy; however, there are even ...
An idiosyncratic reaction is defined as an abnormal susceptibility to a drug peculiar to the individual. 11 Idiosyncratic drug reactions (IDRs) are also immune mediated, and may result in severe skin reactions, anaphylaxis, blood dyscrasias, hepatotoxicity, and internal organ involvement.
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Idiosyncratic drug reactions are adverse drug reactions that do not occur in most patients at any dose and do not involve the known pharmacological properties of the drug. Using this definition, adverse reactions, such as cardiac arrhythmias caused by drugs that affect potassium channels, would not be idiosyncratic because they involve known ...
