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Feb 9, 2020 · Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that can vary by drug and patient. The complex and unpredictable nature of IADRs combined with the fact that they are rare makes them particularly difficult to predict, diagnose, and treat.
- Merrie Mosedale, Paul B Watkins
- 2020
Study with Quizlet and memorize flashcards containing terms like (Idiosyncrasy/drug allergies) are hypersensitization reactions, Idiosyncrasy is an unanticipated drug response due to a (mono/poly)genetic mode of inheritance, Drug idiosyncrasies usually affect drug (distribution/metabolism/targets) and more.
Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow.
- Jack Uetrecht, Dean J. Naisbitt
- 10.1124/pr.113.007450
- 2013
- Pharmacol Rev. 2013 Apr; 65(2): 779-808.
Idiosyncratic reactions represent the largest problem for safety because of their unpredictable nature, and therefore they introduce a significant degree of risk into the process of drug development. An understanding of the basic mechanisms of idiosyncratic drug reactions is essential for predicting risk.
There are three principal hypotheses for how reactive metabolites might induce an immune-mediated idiosyncratic reaction: the hapten hypothesis, the danger hypothesis, and the PI hypothesis.
May 2, 2018 · Idiosyncrasy is not a drug allergy, but both are forms of adverse drug reaction. Idiosyncratic drug reactions are unrelated to the dose of the drug. Common lifethreatening idiosyncratic drug reactions include DRESS syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome.
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Apr 22, 2005 · Major drug toxicities can be grouped into four categories on the basis of their underlying mechanism: hypersensitivity and related immunological reactions; off-target pharmacology; biological...
