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Study with Quizlet and memorize flashcards containing terms like (Idiosyncrasy/drug allergies) are hypersensitization reactions, Idiosyncrasy is an unanticipated drug response due to a (mono/poly)genetic mode of inheritance, Drug idiosyncrasies usually affect drug (distribution/metabolism/targets) and more.
Study with Quizlet and memorize flashcards containing terms like phenylbutazone, fenbendazole, flucytosine and more.
Study with Quizlet and memorize flashcards containing terms like idiosyncratic reaction, paradoxical reaction, Parenteral and more.
Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow.
- Jack Uetrecht, Dean J. Naisbitt
- 10.1124/pr.113.007450
- 2013
- Pharmacol Rev. 2013 Apr; 65(2): 779-808.
- Pharmacological Definition of Idiosyncrasy
- Pathophysiology of Idiosyncratic Drug Reactions
- Classical Examples of Drug-Induced Idiosyncratic Reactions
The definition from Textbook of Pharmacologyby Seth is: That's probably as good as it gets. It is impossible to give a clear official definition for exam purposes because the term, as Uetrecht and Nasibitt put it, "has been used in various ways and has no clear definition". These authors decided to describe it as That is quite different from Goodma...
Idiosyncratic reactions are generally thought to be immune-mediated. There is no agreement on their precise mechanism, and there are many exceptions to contradict every hypothesis. In summary: 1. Either the drug itself, or a reactive metabolite, binds to a protein 2. That protein undergoes a chemical and morphological change, breaking self-toleranc...
There is the distinct possibility that some cruel viva scenario will call for the sweating exam candidate to produce a list of idiosyncratic drug reactions as examples. A solid offering from the literature is hard to find. Here is a short list which was generated by combing through the article by Knowles et al (2000) and Park et al (1992)
Idiosyncratic adverse drug reactions result from mechanisms that are not currently understood. This type of adverse drug reaction is largely unpredictable. Examples of such adverse drug reactions include rashes, jaundice, anemia, a decrease in the white blood cell count, kidney damage, and nerve injury that may impair vision or hearing.
People also ask
How are idiosyncratic drug reactions different from pharmacological effects?
What are idiosyncratic drug reactions?
Are idiosyncratic drug reactions concentration dependent?
What are idiosyncratic responses?
Idiosyncratic drug reactions, also known as type B reactions, are drug reactions that occur rarely and unpredictably amongst the population. This is not to be mistaken with idiopathic, which implies that the cause is not known.
