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Study with Quizlet and memorize flashcards containing terms like (Idiosyncrasy/drug allergies) are hypersensitization reactions, Idiosyncrasy is an unanticipated drug response due to a (mono/poly)genetic mode of inheritance, Drug idiosyncrasies usually affect drug (distribution/metabolism/targets) and more.
Study with Quizlet and memorize flashcards containing terms like phenylbutazone, fenbendazole, flucytosine and more.
A patient has a cytotoxic reaction triggering the complement cascade. What type of immune reaction is this? What cell mediates this?
- Pharmacological Definition of Idiosyncrasy
- Pathophysiology of Idiosyncratic Drug Reactions
- Classical Examples of Drug-Induced Idiosyncratic Reactions
The definition from Textbook of Pharmacologyby Seth is: That's probably as good as it gets. It is impossible to give a clear official definition for exam purposes because the term, as Uetrecht and Nasibitt put it, "has been used in various ways and has no clear definition". These authors decided to describe it as That is quite different from Goodma...
Idiosyncratic reactions are generally thought to be immune-mediated. There is no agreement on their precise mechanism, and there are many exceptions to contradict every hypothesis. In summary: 1. Either the drug itself, or a reactive metabolite, binds to a protein 2. That protein undergoes a chemical and morphological change, breaking self-toleranc...
There is the distinct possibility that some cruel viva scenario will call for the sweating exam candidate to produce a list of idiosyncratic drug reactions as examples. A solid offering from the literature is hard to find. Here is a short list which was generated by combing through the article by Knowles et al (2000) and Park et al (1992)
The propensity of a drug to cause an idiosyncratic reaction is dependent on its chemical characteristics, but individual susceptibility is determined by patient-specific factors, in particular the expression of immunologic receptors that display drug-derived antigens on the cell surface.
- Jack Uetrecht, Dean J. Naisbitt
- 10.1124/pr.113.007450
- 2013
- Pharmacol Rev. 2013 Apr; 65(2): 779-808.
Idiosyncratic. Dose-related adverse drug reactions represent an exaggeration of the drug's therapeutic effects. For example, a person taking a medication to reduce high blood pressure may feel dizzy or light-headed if the medication reduces blood pressure too much.
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Does a drug cause an idiosyncratic reaction?
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What is an idiosyncratic drug?
An idiosyncratic reaction is defined as an abnormal susceptibility to a drug peculiar to the individual. 11 Idiosyncratic drug reactions (IDRs) are also immune mediated, and may result in severe skin reactions, anaphylaxis, blood dyscrasias, hepatotoxicity, and internal organ involvement.
