Search results
Study with Quizlet and memorize flashcards containing terms like (Idiosyncrasy/drug allergies) are hypersensitization reactions, Idiosyncrasy is an unanticipated drug response due to a (mono/poly)genetic mode of inheritance, Drug idiosyncrasies usually affect drug (distribution/metabolism/targets) and more.
Study with Quizlet and memorize flashcards containing terms like phenylbutazone, fenbendazole, flucytosine and more.
Study with Quizlet and memorize flashcards containing terms like idiosyncratic reaction, paradoxical reaction, Parenteral and more.
Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow.
- Jack Uetrecht, Dean J. Naisbitt
- 10.1124/pr.113.007450
- 2013
- Pharmacol Rev. 2013 Apr; 65(2): 779-808.
Idiosyncratic. Dose-related adverse drug reactions represent an exaggeration of the drug's therapeutic effects. For example, a person taking a medication to reduce high blood pressure may feel dizzy or light-headed if the medication reduces blood pressure too much.
The causes of drug toxicity can be organized in several ways and include mechanism-based (on-target) toxicity, immune hypersensitivity, off-target toxicity, and bioactivation/covalent modification. In addition, idiosyncratic responses are rare but one of the most problematic issues; several hypotheses for these have been advanced.
People also ask
What are idiosyncratic drug reactions?
What are idiosyncratic responses?
What is an idiosyncratic drug?
What is idiosyncrasy in pharmacology?
May 2, 2018 · Idiosyncrasy is not a drug allergy, but both are forms of adverse drug reaction. Idiosyncratic drug reactions are unrelated to the dose of the drug. Common lifethreatening idiosyncratic drug reactions include DRESS syndrome, toxic epidermal necrolysis and Stevens-Johnson syndrome.
