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Jul 4, 2023 · Hereditary spherocytosis (HS) is the most prevalent cause of hemolytic anemia due to an abnormal red cell membrane and classifies as a type of congenital hemolytic anemia. Oskar Minkowsky first described it in the early 1900s. [1]
- Edgar A. Zamora, Catherine A. Schaefer
- 2023/07/04
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- What Is Hereditary spherocytosis?
- Who Is Affected by Hereditary spherocytosis?
- How Does Hereditary Spherocytosis Affect My body?
Hereditary spherocytosis is an inherited blood disorder that causes hemolytic anemia. This anemia happens when your red blood cellsbreak down faster than normal. In hereditary spherocytosis, your red blood cells lose their characteristic disk-like shape, becoming round or spherical cells (spherocytes) that are removed from circulation faster than n...
Hereditary spherocytosis typically affects people who have Northern Europe or North American ancestry. (Northern Europe is the northern part or region of the European continent.) Data vary on how many people have hereditary spherocytosis. Healthcare providers estimate that 1 person in 2,000 to 5,000 people worldwide may have hereditary spherocytosi...
In addition to developing hemolytic anemia, most people who have hereditary spherocytosis may have the following conditions: 1. Enlarged spleen (splenomegaly): People develop enlarged spleens in hereditary spherocytosis when their spleens fill up with spherocytes. Blood cells flow through your spleen, navigating several narrow passages before movin...
Oct 25, 2023 · Although relatively rare, hereditary spherocytosis (HS) is the most common cause of hemolytic anemia due to a red cell membrane defect. It is a result of heterogeneous alterations in one of five genes that encode red blood cell (RBC) membrane proteins involved in vertical associations that link the membrane cytoskeleton to the lipid bilayer.
Oct 24, 2021 · Hereditary spherocytosis (HS) is a hereditary hemolytic anemia caused by the mutations in the genes encoding erythrocyte membrane proteins and is mostly inherited in an autosomal dominant manner. , , HS is classified into four types according to the severity of the disease: trait, mild, moderate, and severe.
- Yangyang Wu, Lin Liao, Faquan Lin
- J Clin Lab Anal. 2021 Dec; 35(12): e24034.
- 10.1002/jcla.24034
- 2021/12
Hereditary spherocytosis (HS) is a congenital hemolytic disorder wherein a genetic mutation coding for a structural membrane protein phenotype causes the red blood cells to be sphere-shaped (spherocytosis), rather than the normal biconcave disk shape.
Mar 6, 2023 · Hereditary or congenital spherocytosis is an inherited condition where the red blood cells are spherical instead of the usual disk shape. It can lead to jaundice, hemolytic anemia, and an...
Jun 9, 2018 · This breakdown process is called hemolytic anemia. A normal red blood cell can live for up to 120 days, but red blood cell with hereditary spherocytosis might live for as few as 10 to 30 days.
