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The same insulin if taken in overdose in these patients or in non-diabetics can lead to hypoglycemic coma which can have varied outcome from complete reversal to death. Since the introduction of insulin therapy in 1921, diabetics have used insulin overdose as a mode of suicide. [ 1]
- Figure - PMC - National Center for Biotechnology Information
We report a 27-year-old paramedical lady with no known...
- Characteristics of fatal insulin overdoses - PMC
The current study has shown that suicides using insulin...
- Figure - PMC - National Center for Biotechnology Information
The value of LD 50 for a substance is the dose required to kill half the members of a tested population after a specified test duration. LD 50 figures are frequently used as a general indicator of a substance's acute toxicity. A lower LD 50 is indicative of higher toxicity.
Jan 18, 2023 · Because insulin is a known lethal drug, it is sometimes used by patients for intentional overdose. Insulin may also be used by relatives of people with diabetes in this way.
Mortality in attempted suicidal overdose with insulin is 25%. Death has occurred after as little as 20 units but doses of 400 to 900 units or more are more common in fatal cases. Irreversible neurological injury occurs when glycogen stores are depleted since the brain is totally dependent on glucose metabolism.
Nov 3, 2020 · Adult: 50ml bolus of 50% dextrose IV, repeat as required. Children: 2 ml/kg of 10% dextrose IV, repeat as required. Repeated hypoglycaemia: commence 10% glucose infusion, starting at 100ml and hour and monitor the blood glucose (children start maintenance fluids with o.9% saline and 5% dextrose +/- potassium).
Dec 18, 2017 · Severe insulin overdose usually occurs as a suicide attempt, but can also result from medication error. Conventional therapy focuses on giving tons of intravenous glucose. This generally works, but it can get messy: In severe cases, central line placement is needed to administer D20W or D50W infusion.
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