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During development, tissues are replaced by bone during the ossification process. In intramembranous ossification, bone develops directly from sheets of mesenchymal connective tissue. In endochondral ossification, bone develops by replacing hyaline cartilage.
- Lindsay M. Biga, Sierra Dawson, Amy Harwell, Robin Hopkins, Joel Kaufmann, Mike LeMaster, Philip Mat...
- 2019
Apr 9, 2024 · Bone ossification is the formation of new bone, which can occur in two ways: intramembranous ossification and endochondral ossification. This article will discuss both forms as well as clinically relevant examples.
By the sixth or seventh week of embryonic life, the actual process of bone development, ossification (osteogenesis), begins. There are two osteogenic pathways—intramembranous ossification and endochondral ossification—but bone is the same regardless of the pathway that produces it.
Oct 30, 2023 · Reading time: 8 minutes. Bone formation in a developing embryo begins in mesenchyme and occurs through one of two processes: either endochondral or intramembranous osteogenesis (ossification). Intramembranous ossification is characterized by the formation of bone tissue directly from mesenchyme.
- Julie Doll
- Content Manager
- Intramembranous Ossification
- Endochondral Ossification
- Growth of Bone
- Bone Remodeling and Repair
Intramembranous ossificationis the process of bone development from fibrous membranes. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles. Ossification begins as mesenchymal cells form a template of the future bone. They then differentiate into osteoblasts at the ossification center. Osteoblasts secrete ...
Endochondral ossificationis the process of bone development from hyaline cartilage. All of the bones of the body, except for the flat bones of the skull, mandible, and clavicles, are formed through endochondral ossification. In long bones, chondrocytes form a template of the hyaline cartilage diaphysis. Responding to complex developmental signals, ...
Long bones continue to lengthen, potentially until adolescence, through the addition of bone tissue at the epiphyseal plate. They also increase in width through appositional growth.
Bone renewal continues after birth into adulthood. Bone remodelingis the replacement of old bone tissue by new bone tissue. It involves the processes of bone deposition by osteoblasts and bone resorption by osteoclasts. Normal bone growth requires vitamins D, C, and A, plus minerals such as calcium, phosphorous, and magnesium. Hormones such as para...
Ossification. Bone is broken down by osteoclasts, and rebuilt by osteoblasts, both of which communicate through cytokine (TGF-β, IGF) signalling. Ossification (also called osteogenesis or bone mineralization) in bone remodeling is the process of laying down new bone material by cells named osteoblasts.
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Is ossification a replacement process?
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What is bone ossification?
Is endochondral ossification a replacement process?
All bone formation is a replacement process. Embryos develop a cartilaginous skeleton and various membranes. During development, these are replaced by bone during the ossification process. In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length.
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