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Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an atypical protein is found in the blood. The protein is called monoclonal protein or M protein.
This protein is made in the soft, blood-producing tissue in the center of bones. This blood-producing tissue is bone marrow. Monoclonal gammopathy of undetermined significance occurs most often in older men.
MGUS usually causes no problems. But sometimes it can lead to more-serious diseases. These include some forms of blood ...
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People with monoclonal gammopathy often don't have symptoms. Some people have a rash or nerve problems, such as numbness or tingling. A blood test for another condition might find MGUS by chance.
Experts don't know what causes MGUS. Changes in genes and being around certain chemicals, such as those used to kill pests, appear to play a role.
MGUS doesn't require treatment. But your health care provider is likely to have you get regular checkups to watch the condition. Checkups likely will start six months after your diagnosis.
For those at high risk of MGUS leading to a more serious condition, more-frequent checkups can watch the disease. That way, treatment can start as soon as possible if it's needed.
Symptoms to watch for include:...
For informational purposes only and not a substitute for professional medical advice, diagnosis, or treatment.
© Mayo Clinic
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