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1-( I-Pheiiylcyclohesyl)piperidine, the first compouiid of this type synthesized, was prepared from I-piperidinocyclohexanecarbonitrile by replacement of the cyano . group by phenyl using phenylmagnesirim bromide. These compoimds were kited for cataleptoid itctivity and antitonic extensor properties.
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Planning a Synthesis using a Reductive Amination. If you are trying to develop a synthesis of an amine molecule, the key bond break is a C-N bond in the target molecule. There may be multiple C-N bonds present, so each should be broken separately to produce a possible set of starting materials.
Jan 1, 2016 · Arylcyclohexamines (also known as arylcyclohexylamines) are a group of compounds that contain a cyclohexamine unit with an aryl moiety, typically a phenyl ring, attached to the same atom to which the amine group is linked (see Fig. 1).
Typical potential energy curves for exothermic and endothermic reactions. It is obvious from the potential energy diagrams that the enthalpy change is positive for an endothermic reaction (ΔH > 0) and negative for an exothermic reaction (ΔH > 0).
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A series of phencyclidine homologs was synthesized by reductive cyclization of substituted ω-chlorine-substituted l-N- [l- (p-hydroxybenzyl)cyclohexyl]amides with LiAlH4 by characterized and tested for neurotropic activity. Expand. 1. Synthesis and biological activity of cyclohexylamine derivatives. V. A. Glushkov O. S. P’yankova. +4 authors.
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Sep 7, 2023 · New derivatives ( II-IV) were synthesized with changing of substituting on aromatic, cyclohexyl, and amine moieties of PCP. In vivo evaluation of acute and chronic pain activities of the new compounds were carried out by applying tail immersion and formalin tests on mice.
