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St. Louis. The Gateway City of St. Louis is the epitome of the modern Midwestern metropolis. Missouri's second-largest city is vibrant but laid-back, populous but navigable, historic but still relevant. Map.
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Coordinates: 38°37′38″N 90°11′52″W. St. Louis (/ seɪnt ˈluːɪs, sənt -/ saynt LOO-iss, sənt-) [11] is an independent city in the U.S. state of Missouri. It is located near the confluence of the Mississippi and the Missouri rivers.
Satellite view showing St. Louis, an independent city in east-central Missouri United States, located on the west bank of the Mississippi River opposite East St. Louis.
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