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Table 1 Statin Dosing and ACC/AHA Classification of Intensity. From ACC / AHA, 2018. 199 Dosages shown are total daily dosages; exceptions are noted. Abbreviations: ACC =American College of Cardiology; AHA =American Heart Association; LDL-C =low-density lipoprotein cholesterol; NA=not applicable.
Feb 17, 2023 · Statins are often categorized by how much they lower LDL (“bad”) cholesterol. This is referred to as statin “intensity,” which is divided into three categories: low, moderate, and high. The best statin and dosage for you depends on several factors.
If statins are indicated, reduce LDL-C levels by ≥30%, and if 10-year risk is ≥20%, reduce LDL-C levels by ≥50%. 7 In adults 40 to 75 years of age without diabetes mellitus and with LDL-C levels ≥70 mg/dL (≥1.8 mmol/L), at a 10-year ASCVD risk of ≥7.5%, start a moderate-intensity statin if a
ASCVD risk, begin high-intensity statin therapy. If the LDL-C level remains ≥100 mg/dL (≥2.6 mmol/L), adding ezetimibe is reasonable. If the LDL-C level on statin plus ezetimibe remains ≥100 mg/dL (≥2.6 mmol/L) and the patient has multiple factors that increase subsequent risk of ASCVD events, a PCSK9 inhibitor may be consid-
Therefore, moderate-intensity statin therapy is indicated for primary prevention in patients 40 to 75 years of age with diabetes. 4. Patients with primary severe hypercholesterolemia (LDL-C ≥190 mg/dL [≥4.9 mmol/L]) have a high risk of ASCVD S4.3-23 and premature and recurrent coronary events.
cholesterol management (refer to chart for full guidelines) • In patients with severe primary hypercholesterolemia (LDL-C level ≥190 mg/dL preeclampsia, premature menopause) (≥4.9 mmol/L)), begin high-intensity statin therapy without calculating 10-year ASCVD risk. • In patients 40 to 75 years of age with diabetes
Note: The shading reflects doses listed in the ACC/AHA Guideline on Treatment of Blood Cholesterol (2013) as reflecting high-intensity therapy (≥ 50% reduction in LDL-C, darker shading) and moderate-intensity therapy (30% to 50% reduction in LDL-C, lighter shading).
Jul 1, 2023 · As you can see by the table below, a statin can fall into more than one intensity category, depending on the dosage. For example, 10 or 20 mg of atorvastatin daily is considered moderate intensity, while 40 to 80 mg is high intensity. The choice of a statin depends on a person's risk.
Apr 15, 2021 · Strong evidence supports moderate-dose statins as the best therapy in primary prevention for patients at elevated risk, with relative risk reductions in cardiovascular events and mortality of 20%...
May 1, 2019 · High-quality evidence from RCTs recommends that patients 40 to 75 years of age without diabetes who are at intermediate risk with LDL-C levels of 70 to 189 mg per dL (1.81 to...
