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- Idiosyncratic adverse drug reactions result from mechanisms that are not currently understood. This type of adverse drug reaction is largely unpredictable. Examples of such adverse drug reactions include rashes, jaundice, anemia, a decrease in the white blood cell count, kidney damage, and nerve injury that may impair vision or hearing.
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The term idiosyncratic drug reaction (IDR) has been used in various ways and has no clear definition, but the term is used in this review to designate an adverse reaction that does not occur in most patients treated with a drug and does not involve the therapeutic effect of the drug.
- Figure - PMC - National Center for Biotechnology Information
Idiosyncratic drug reactions are a significant cause of...
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- Idiosyncratic adverse drug reactions: current concepts - PubMed
Idiosyncratic drug reactions are a significant cause of...
- Idiosyncratic drug reactions: current understanding - PubMed
Clinical characteristics and circumstantial evidence suggest...
- Figure - PMC - National Center for Biotechnology Information
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Jun 25, 2020 · Idiosyncratic adverse drug reactions (IADRs) encompass a diverse group of toxicities that can vary by drug and patient. The complex and unpredictable nature of IADRs combined with the fact that they are rare makes them particularly difficult to predict, diagnose, and treat.
- Merrie Mosedale, Paul B Watkins
- 2020
Mar 8, 2013 · Idiosyncratic drug reactions are a significant cause of morbidity and mortality for patients; they also markedly increase the uncertainty of drug development. The major targets are skin, liver, and bone marrow. Clinical characteristics suggest that IDRs are immune mediated, and there is substantive ….
Oct 10, 2022 · The most common type of IDR leading to drug candidate failure is idiosyncratic drug-induced liver injury (IDILI), and most drug metabolism occurs in the liver. If reactive metabolites are responsible for IDRs, screening for their formation should lead to safer drug candidates.
- Jack Uetrecht, *
- 2022/10/10
- 10.1021/acs.chemrestox.2c00090
Jan 6, 2020 · An idiosyncratic adverse drug reaction is a type that is not widely understood and its severity is often quite unpredictable. This affects the fewer people and the reason for the adverse reaction may be genetically predetermined [ 9 ].
- Hanan Khalil, Hanan Khalil, C Huang
- 10.1186/s12913-019-4651-7
- 2020
- BMC Health Serv Res. 2020; 20: 5.
Jan 1, 2024 · Idiosyncratic drug reactions (IDRs) are unanticipated toxicities that are not linked to a drug's known pharmacological effects. These reactions are unpredictable, often arising infrequently in short-term safety studies, and can even be rare clinically.
Clinical characteristics and circumstantial evidence suggest that idiosyncratic drug reactions are caused by reactive metabolites and are immune-mediated; however, there are few definitive data and there are likely exceptions.
