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   What are the risk factors for sepsis?

   • All types of infections can lead to sepsis, but there are certain risk factors that can increase your risk of developing it. For example, people who are very young or elderly are at particularly high risk for developing sepsis. Other sepsis risk factors include:

   Early Signs of Sepsis: Symptoms, Treatment, and When to Seek Care

   www.verywellhealth.com/early-signs-of-sepsis-5498608

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   What types of infections cause sepsis?

   • Any type of infection can lead to sepsis. This includes bacterial, viral or fungal infections. Those that more commonly cause sepsis include infections of: Lungs, such as pneumonia. Kidney, bladder and other parts of the urinary system. Digestive system. Bloodstream. Catheter sites. Wounds or burns.

   Sepsis - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org/diseases-conditions/sepsis/symptoms-causes/syc-20351214

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   What causes sepsis & systemic inflammatory response syndrome (SIRS)?

   • The clinical manifestations of sepsis and the systemic inflammatory response syndrome (SIRS) can be attributed to components of the innate immune response [ 19 ]. At present at least five lines of innate immunity defense against sepsis-causing bacteria are identified. Bacteria usually first enter host tissues.

   Sepsis: mechanisms of bacterial injury to the patient - PMC

   www.ncbi.nlm.nih.gov/pmc/articles/PMC6376788/

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2. www.mayoclinic.org › diseases-conditions › sepsisSepsis - Symptoms & causes - Mayo Clinic

   www.mayoclinic.org › diseases-conditions › sepsis

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   Feb 10, 2023 · Symptoms of sepsis may include: Change in mental status. Fast, shallow breathing. Sweating for no clear reason. Feeling lightheaded. Shivering. Symptoms specific to the type of infection, such as painful urination from a urinary tract infection or worsening cough from pneumonia. Symptoms of sepsis are not specific.

3. www.verywellhealth.com › early-signs-of-sepsis-5498608Early Signs of Sepsis: Symptoms and When to Seek Care

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   2 days ago · Early signs of sepsis may include a change in mental status and very fast breathing. Common signs of sepsis include: Fever or low body temperature (hypothermia) Shortness of breath. Shivering or chills. Severe pain or discomfort. Confusion or delirium. Lightheadedness due to low blood pressure. Rapid heartbeat.

4. www.ncbi.nlm.nih.gov › pmc › articlesBacterial virulence plays a crucial role in MRSA sepsis - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 25, 2021 · These models, which explain differences in sepsis outcome predominantly by host factors, can hardly explain the clinically observed increased morbidity and mortality that is associated with specific pathogens such as S. aureus . In this study we hypothesized that bacterial virulence significantly affects sepsis development and outcome.

   • Author: Gordon Y. C. Cheung, Justin S. Bae, Ryan Liu, Rachelle L. Hunt, Yue Zheng, Michael Otto
   • DOI: 10.1371/journal.ppat.1009369

   • Publish Year: 2021
   • Publication: PLoS Pathog. 2021 Feb; 17(2): e1009369.

5. my.clevelandclinic.org › health › diseasesSepsis: Symptoms, Causes, Treatment & Prevention

   my.clevelandclinic.org › health › diseases

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   Jan 19, 2023 · Sepsis can affect many different areas of your body, so there are many possible symptoms. If an infection such as blood poisoning ( septicemia) triggered your condition, you may develop a sepsis rash on your skin. The rash makes your skin appear red and discolored. You may see small, dark-red spots on your skin.

6. www.ncbi.nlm.nih.gov › pmc › articlesSepsis: mechanisms of bacterial injury to the patient - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 14, 2019 · Bacterial toxins. The mechanisms by which bacteria cause sepsis and septic shock involve bacterial factors (cell wall, secreted products) and host factors (susceptibility, primary (immune) response, secondary (tissue) response, etc.) [ 93 ]. Bacterial toxins allow the pathogen to modulate host defenses.

   • Author: Hayk Minasyan

   • Publish Year: 2019

7. www.merckmanuals.com › sepsis-and-septic-shockSepsis and Septic Shock - Critical Care Medicine - Merck ...

   www.merckmanuals.com › sepsis-and-septic-shock

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   Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by a dysregulated response to infection. In septic shock, there is critical reduction in tissue perfusion and acute failure of multiple organs, including the lungs, kidneys, and liver, can occur. Common causes in immunocompetent patients include many different species of ...

8. www.sepsis.org › sepsis-basics › symptomsSymptoms | Sepsis Alliance

   www.sepsis.org › sepsis-basics › symptoms

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   M – Mental decline – confused, sleepy, difficult to rouse. Sepsis can affect your mental status. Some people, especially the elderly, may not show typical signs of infection. Instead, they may show a sudden change in mental status, becoming confused, or a worsening of dementia and confusion. Sleepiness, often severe, is also a common complaint.