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- Nitrates are converted into nitrites by bacteria in our saliva, stomach, and intestines, and it is primarily the nitrites that cause toxicity. Nitrites oxidize the iron component of red blood cells (hemoglobin), rendering them unable to carry oxygen.
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Abstract. Sodium nitrite is a powerful oxidizing agent that causes hypotension and limits oxygen transport and delivery in the body through the formation of methemoglobin. Clinical manifestations can include cyanosis, hypoxia, altered consciousness, dysrhythmias, and death.
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Jul 15, 2023 · First Aid & Emergencies. Reference. Sodium Nitrite Toxicity. Medically Reviewed by Sabrina Felson, MD on July 15, 2023. Written by Alexandra Benisek. What Is Sodium Nitrite Used For? What...
Misuse or excessive use of any medicine or product containing nitrates, whether unintentionally or intentionally, can lead to poisoning. Poisoning can result from swallowing, inhaling, or even skin contact. People have been poisoned after drinking nitrate-contaminated rural well water.
Acute acquired methemoglobinemia is the most important adverse health effect caused by excessive nitrate/nitrite exposure. The known toxic effects from nitrate exposure result from the conversion of nitrate to nitrite.
