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- In warm autoimmune hemolytic anemia (AIHA), erythrocytes opsonized with immunoglobulin (typically IgG) are destroyed by the mono-nuclear phagocytic system, mainly in the spleen and partly after transformation to spherocytes.
Nov 20, 2020 · The pathogenesis of AIHA is complex and still not fully understood. Recent studies indicate the involvement of T and B cell dysregulation, reduced CD4+ and CD25+ Tregs, increased clonal expansions of CD8 + T cells, imbalance of Th17/Tregs and Tfh/Tfr, and impaired lymphocyte apoptosis.
- Sylwia Sulimiera Michalak, Anna Olewicz-Gawlik, Anna Olewicz-Gawlik, Joanna Rupa-Matysek, Edyta Woln...
- 10.1186/s12979-020-00208-7
- 2020
- Immun Ageing. 2020; 17: 38.
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What is autoimmune hemolytic anemia (AIHA)?
What is the pathogenesis of warm autoimmune hemolytic anemia (AIHA)?
What are the serological types of autoimmune hemolytic anemia (AIHA)?
What is warm autoimmune hemolytic anemia?
Nov 30, 2018 · Autoimmune hemolytic anemia (AIHA) is a decompensated acquired hemolysis caused by the host’s immune system acting against its own red cell antigens. Consequent complement activation can impact the clinical picture and is an emerging target for therapeutic approaches.
- Anita Hill, Quentin A. Hill
- 2015
Jun 14, 2022 · Autoimmune hemolytic anemia (AIHA) is a rare disease with an incidence of 0.8 to 3/100,000 people per year and is caused by an autoimmune attack against erythrocyte antigens [Citation 1, Citation 2]. While accumulated knowledge exists about disease pathogenesis, the etiology of AIHA is still largely obscure and considered ‘multifactorial.’
Oct 6, 2021 · Autoimmune hemolytic anemia (AIHA) is defined as increased destruction of red cells through autoimmune mechanisms, usually mediated by autoantibodies against erythrocyte surface antigens....
- Sigbjørn Berentsen, Wilma Barcellini
- 2021
- What Is Autoimmune Hemolytic Anemia?
- What’s The Difference Between Primary and Secondary Autoimmune Hemolytic Anemia?
- What Are The Types of Autoimmune Hemolytic Anemia?
- Who Does Autoimmune Hemolytic Anemia Affect?
- How Common Is Autoimmune Hemolytic Anemia?
Autoimmune hemolytic anemia (AIHA) occurs when your immune system mistakes red blood cells as unwanted substances. As a result, your body produces antibodies that destroy red blood cells, which can lead to a low amount of red blood cells (known as anemia). AIHA is highly manageable, but it can be fatal if left untreated. Immediate intervention is e...
If your AIHA develops without the obvious presence of an underlying condition, it’s called primary AIHA. Secondary AIHAis when it’s linked to another condition, such as a viral illness, other autoimmune diseases, medication or underlying blood cancer (such as lymphoma).
There are two main types of autoimmune hemolytic anemia: warm autoimmune hemolytic anemia and cold autoimmune hemolytic anemia. This classification depends on the type of antibodies involved in the disease.
AIHA can affect people of all ages and genders, though it most commonly occurs in females over the age of 40.
Autoimmune hemolytic anemia is rare, affecting approximately 1 to 2 out of every 100,000 people each year.
Dec 9, 2022 · Warm autoimmune hemolytic anemia (wAIHA) is characterized by evidence of red blood cell (RBC) hemolysis and a direct antiglobulin test positive for IgG and sometimes complement.
destruction of red cells through autoimmune mechanisms, usually mediated by autoantibodies against erythrocyte surface antigens.1-3 During the past decade, important new findings have emerged...
