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- Princeton geneticist and Howard Hughes Medical Institute Investigator Bonnie Bassler helped lead a revolution in the way scientists think about bacteria. Her lab's work on quorum sensing—essentially how bacteria "talk" with one another and act as groups—has spawned a flurry of medical research and may one day bring us a new class of drugs.
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Bonnie Lynn Bassler (born 1962) is an American molecular biologist; the Squibb Professor in Molecular Biology and chair of the Department of Molecular Biology at Princeton University; and a Howard Hughes Medical Institute Investigator.
Oct 24, 2013 · She elucidated the chemical language that bacteria use to communicate through a process called quorum sensing that allows bacteria to count their numbers, determine when they’ve reached a critical mass, and then change their behavior in unison to result in virulence or even bioluminescence.
- Ushma S. Neill
- 10.1172/JCI75027
- 2014
- J Clin Invest. 2014 Apr 1; 124(4): 1421-1422.
Bassler’s research is paving the way to the development of novel therapies for combating bacteria by disrupting quorum-sensing-mediated communication. At Princeton, Dr. Bassler teaches both undergraduate and graduate courses.
By contrast, in biochemistry and molecular biology courses I could use logic to solve puzzles, and I was thrilled by the wondrous, miniature building blocks that made life possible: DNA, RNA, and proteins. I changed my major to biochemistry and my Grade Point Average soared.
Bonnie Bassler describes how quorum sensing might be manipulated to cure diseases and why it is important to understand quorum sensing in natural environments in which bacteria normally live. Quorum-Sensing Interference Strategies
Jan 1, 2007 · Princeton's Bonnie Bassler has lead a revolution in the way scientists think about bacteria. Her lab's work on quorum sensing—essentially how bacteria "talk" with one another and act as groups...
Jan 5, 2022 · Princeton geneticist Bonnie Bassler will receive the 2020 Gruber Genetics Prize for her pioneering work on intercellular bacterial communication. Her research has expanded our understanding of microbes and opened up new approaches to promoting health and preventing disease.
