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May 19, 2022 · Hereditary spherocytosis is an inherited blood disorder that causes hemolytic anemia. This anemia happens when your red blood cells break down faster than normal. In hereditary spherocytosis, your red blood cells lose their characteristic disk-like shape, becoming round, or spherical cells (spherocytes), that can’t function like normal red ...
Feb 14, 2024 · Hereditary spherocytosis is a genetic disorder in which the red blood cells (RBCs) are fragile and burst easily. These disc-shaped cells, which have a lifespan of 120 days, contain hemoglobin...
Jul 4, 2023 · Hereditary spherocytosis results from a deficiency in one or more proteins involved in maintaining adequate adherence between the cytoskeleton and bilipid membrane. As the cellular surface is unable to be adequately supported by the cytoskeleton, the cell adopts an abnormal sphere shape that decreases surface to volume relationship.
- Edgar A. Zamora, Catherine A. Schaefer
- 2023/07/04
Hereditary spherocytosis (HS) is a congenital hemolytic disorder wherein a genetic mutation coding for a structural membrane protein phenotype causes the red blood cells to be sphere-shaped (spherocytosis), rather than the normal biconcave disk shape.
In about 75 percent of cases, hereditary spherocytosis is inherited in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some cases, an affected person inherits the mutation from one affected parent.
Jan 1, 2024 · If you inherit only one abnormal gene, you are called a carrier. Carriers do not have the disorder, as they have one normal gene which is enough to make normal-shaped red blood cells. However, carriers can pass the abnormal gene on to their children.
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Mar 15, 2023 · Spherocytosis is the production of red blood cells (erythrocytes) that are in the shape of a sphere (spherocytes) instead of the concave disk shape that is normal for red blood cells. These spherocytes are abnormal, fragile, and possess a short lifespan as compared to normal red blood cells.
