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Hereditary spherocytosis (HS) is a heterogeneous group of disorders with regard to clinical severity, protein defects and mode of inheritance. It is relatively common in Caucasian populations; most affected individuals have mild or only moderate haemolysis.
Hereditary spherocytosis is a disease involving five membrane proteins that are in close contact with each other in the red cell membrane. 1.1 Organisation of red blood cell membrane
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Jul 4, 2023 · Introduction. Hereditary spherocytosis (HS) is the most prevalent cause of hemolytic anemia due to an abnormal red cell membrane and classifies as a type of congenital hemolytic anemia. Oskar Minkowsky first described it in the early 1900s. [1] .
- Edgar A. Zamora, Catherine A. Schaefer
- 2023/07/04
- What Is Hereditary spherocytosis?
- Who Is Affected by Hereditary spherocytosis?
- How Does Hereditary Spherocytosis Affect My body?
Hereditary spherocytosis is an inherited blood disorder that causes hemolytic anemia. This anemia happens when your red blood cellsbreak down faster than normal. In hereditary spherocytosis, your red blood cells lose their characteristic disk-like shape, becoming round or spherical cells (spherocytes) that are removed from circulation faster than n...
Hereditary spherocytosis typically affects people who have Northern Europe or North American ancestry. (Northern Europe is the northern part or region of the European continent.) Data vary on how many people have hereditary spherocytosis. Healthcare providers estimate that 1 person in 2,000 to 5,000 people worldwide may have hereditary spherocytosi...
In addition to developing hemolytic anemia, most people who have hereditary spherocytosis may have the following conditions: 1. Enlarged spleen (splenomegaly): People develop enlarged spleens in hereditary spherocytosis when their spleens fill up with spherocytes. Blood cells flow through your spleen, navigating several narrow passages before movin...
Hereditary spherocytosis (HS) is a heterogeneous group of disorders of erythrocytes. The common denominator are structural membrane defects that lead to changes in erythrocyte deformability.
Description. Hereditary spherocytosis is a condition that affects red blood cells. People with this condition typically experience a shortage of red blood cells (anemia), yellowing of the eyes and skin (jaundice), and an enlarged spleen (splenomegaly).
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Feb 14, 2024 · Hereditary spherocytosis is a disorder in which the red blood cells are abnormal and fragile. Learn about the causes, symptoms, and treatment options for this disorder today.
