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Jan 10, 2023 · Neonatal HSV infection causes serious morbidity and mortality and leaves many survivors with permanent sequelae. Strong clinical suspicion, timely diagnosis, and early antiviral treatment are critical to improving outcome. The management and prevention of neonatal HSV infection will be reviewed here.
Symptoms and Signs of Neonatal HSV Infection. Manifestations generally occur between the 1st and 3rd weeks of life but rarely may not appear until as late as the 4th week. Neonates may present with local or disseminated disease. Skin vesicles are common with either type, occurring in about 70% overall.
Presentation can be nonspecific in the absence of skin lesions. In one study reporting the results of HSV testing of all neonates up to 21 days of age being evaluated for sepsis, 31% had mucocutaneous involvement, 19% had seizures, and 50% had nonspecific symptoms (usually fever).
Both HSV-1 and HSV-2 can cause neonatal HSV disease, and to improve overall outcome in infants diagnosed with neonatal HSV disease, early diagnosis and initiation of treatment is imperative. Early initiation of therapy prevents further disease progression ( Kimberlin et al., 2001b ).
About 1 out of every 3,500 babies born in the United States contracts neonatal herpes simplex. The symptoms nearly always appear during the baby’s first month of life. Neonatal herpes simplex is a serious infection that, if not treated, can cause long-term damage to your baby’s health.
Jan 21, 2023 · Bacteria such as E. coli, Listeria and Group B streptococcus (GBS) are common bacteria that can cause infections that lead to sepsis. Viruses, fungi and parasites can also lead to the condition. For instance, the herpes simplex virus (HSV) can cause severe infections in newborns.
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