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      • R. prowazekii multiplies in the gut epithelium of the louse which then detaches, ruptures, and releases rickettsiae into the feces. Rickettsiae from the infected feces enter the skin via abrasions or bite site and access the human host.
      www.ncbi.nlm.nih.gov › books › NBK448173
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  2. Aug 8, 2023 · R. prowazekii multiplies in the gut epithelium of the body louse and explodes into the gastrointestinal (GI) tract, eventually killing the body louse in the process. In this regard, R. prowazekii is unique because no other known members of Rickettsia kill their vector.

    • Sami M. Akram, Megan Ladd, Kevin C. King
    • 2023/08/08
  3. Aug 12, 2021 · R. prowazekii is transmitted from human to human via the body louse (Pediculus humanus), while all other so-far-known rickettsial species are transmitted to humans via ectoparasites from rodents, predominantly from rats and mice. Rodents serve as a natural reservoir and play a key role in the distribution of rickettsial infections.

    • Anke Osterloh
    • 10.3390/vaccines9080896
    • 2021
    • Vaccines (Basel). 2021 Aug; 9(8): 896.
  4. Rickettsia prowazekii infects the midgut epithelium of the louse, is shed in the louse feces, and is inoculated into louse-bitten skin by scratching or when rubbed into mucous membranes. The lice are not adapted to elevated body temperatures.

    • Lucas S. Blanton
    • 2019
  5. R. prowazekii is often surrounded by a protein microcapsular layer and slime layer; the natural life cycle of the bacterium generally involves a vertebrate and an invertebrate host, usually an arthropod, typically the human body louse.

  6. Brill-Zinsser Disease. Epidemic typhus is caused by Rickettsia prowazekii. Symptoms are prolonged high fever, intractable headache, and a maculopapular rash. (See also Overview of Rickettsial and Related Infections.) Epidemic typhus is a rickettsial disease.

  7. Jan 30, 2023 · Some authors theorize that the competence of R. prowazekii is lower in the vector P. humanus capitis than in P. humanus corporis due to the position of the feces, which are more likely to be inhaled from the body than from the head . Rickettsia prowazekii has only been identified in Turkey in Europe; its clinical significance is unknown, and ...

  8. Aug 8, 2023 · Rickettsia prowazekii is an intracellular, gram-negative coccobacillus. It is an obligate parasite. R. prowazekii belongs to the genus Rickettsia and is the causative agent of epidemic typhus. The genus Rickettsia is composed of gram-negative bacteria. Rickettsiae are the closest known relatives of mitochondria in eukaryotic cells.

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