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  1. Brimstone is a passive item. Isaac's tears are replaced with a charged blood laser beam. The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. The laser deals damage equal to Isaac's damage and deals damage each tick.

  2. Brimstone is a passive item. It appears as an alchemical symbol for sulfur. Isaac appears demonic with large curved horns and an angry expression. Picking up Brimstone will multiply Isaac's current damage by 3. It also changes tears to a chargeable laser that pierces all objects in its path...

  3. Welcome back everybody to the long awaited sequel to my most popular video of all time, the BEST SYNERGIES for Brimstone in the Binding of Isaac REPENTANCE! ...

  4. Apr 18, 2021 · This video will quickly showcase most of the new synergies with Brimstone added in The Binding of Isaac: Repentance.

  5. Jul 14, 2021 · Brimstone, probably one of the most iconic items in the franchise of The Binding of Isaac is also the item that got the most changes over the years and versions of the game. This video will...

  6. The beam is piercing and spectral, dealing damage to all enemies and ignoring all obstacles in its path. The laser deals damage equal to Isaac's damage and deals damage each tick. Brimstone ticks 9 times in about 1 second. Tears down: Delay * 3.

  7. Sep 14, 2022 · From the Sacred Heart to the Magic Mushroom and the mighty Brimstone, here are some of the best and strongest items available in The Binding Of Isaac.

  8. Replaces Isaac's tears with a laser beam that must be charged. The beam pierces through enemies and obstacles and has infinite range. The beam deals damage equal to Isaac's damage each tick. Each shot deals damage for 9 ticks, resulting in a total of 9x Isaac's damage in about ~0.63 seconds.

  9. A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage. Each laser deals 3.5 damage per tick, up to 9 times for a total of 31.5 damage.

  10. Click two items on the left to see how they interact! The Afterbirth DLC not only added 120+ new items, but a whole host of new weapon synergies that have pretty darn cool effects. This page should help you figure out which ones you should be looking out for and which to avoid!

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