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Gain-of-function research (GoF research or GoFR) is medical research that genetically alters an organism in a way that may enhance the biological functions of gene products. This may include an altered pathogenesis, transmissibility, or host range, i.e., the types of hosts that a microorganism can infect.
Jul 22, 2021 · Gain-of-function research involves giving a pathogen a new "ability" and is controversial because if a pathogen is mutated to become more infectious or deadly and then escapes from...
May 8, 2023 · From cancer immunotherapy and antibiotics to GMO crops and pandemic surveillance, gain of function is a cornerstone of basic research.
Apr 13, 2015 · TYPES OF GAIN-OF-FUNCTION (GOF) RESEARCH. Subbarao explained that routine virological methods involve experiments that aim to produce a gain of a desired function, such as higher yields for vaccine strains, but often also lead to loss of function, such as loss of the ability for a virus to replicate well, as a consequence.
Nov 1, 2021 · What exactly is gain-of-function research, and is it cause for alarm? Researchers have been modifying viruses for decades—and not always in benign ways.
Gain-of-Function research on viruses is enhancing transmissibility, virus replication, virulence, host range, immune evasion or drug and vaccine resistance to get insights into the viral mechanisms, to create and analyze animal models, to accelerate drug and vaccine development and to improve pandemic preparedness.
Oct 27, 2021 · Now, gain-of-function research is once again centre stage, thanks to SARS-CoV-2 and a divisive debate about where it came from. Most virologists say that the coronavirus probably emerged from...
Jun 20, 2016 · Such loss- and gain-of-function experiments allow investigators to understand the complex nature of host-pathogen interactions that underlie transmission, infection, and pathogenesis and can help attribute biological function to genes and proteins.
Sep 15, 2023 · Researchers at Georgetown University’s Center for Security and Emerging Technology in Washington DC scanned the scientific literature using an artificial-intelligence tool to assess where and how...
TYPES OF GAIN-OF-FUNCTION (GOF) RESEARCH. Subbarao explained that routine virological methods involve experiments that aim to produce a gain of a desired function, such as higher yields for vaccine strains, but often also lead to loss of function, such as loss of the ability for a virus to replicate well, as a consequence.
