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  1. May 15, 2024 · Key points. Healthcare providers consider multiple factors when evaluating a patient for Lyme disease. Laboratory diagnosis of Lyme disease relies on a blood test that detects antibodies to the Lyme bacteria. It can take several weeks after infection for the immune system to make enough antibodies to be detected by the test.

    • The First Test: Elisa
    • The Second Test: Western Blot Or A Second Elisa
    • A Possible Drawback of The Two-Step Testing System
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    This blood test is for antibodies against the Lyme disease bacteria. Because it can take some time for your body to produce antibodies, this test isn’t always accurate soon after a person is infected.

    There are two options for the second test. One is called a Western blot, which looks at how your antibodies react to specific parts of the Lyme disease bacteria. The Western blot test has been part of the two-step testing system since 1994 and is more commonly used. The other option is to do a second ELISA test, which measures antibodies to a speci...

    The CDC testing guidelines recommend a second test only if the first test is positive or unclear. Because the first test may not pick up antibodies soon after possible exposure to the Lyme disease bacteria, that means a person with Lyme disease may never get the second test. So, if your ELISA test is negative, you may want to ask your doctor to rep...

    Learn how to diagnose Lyme disease based on symptoms, risk factors, and tick tests. Find out why blood tests can be unreliable and how to get treatment if you have Lyme disease.

  2. May 15, 2024 · CDC currently recommends a two-step testing process for Lyme disease serologic testing. Both steps are required and can be done using the same blood sample. If this first step is negative, no further testing is recommended. If the first step is positive or indeterminate (sometimes called “equivocal”), the second step should be performed.

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  4. Feb 10, 2023 · Learn how Lyme disease is diagnosed and treated with antibiotics, and how to prevent tick bites and complications. Find out about the symptoms, causes, and possible long-term effects of Lyme disease.

  5. Learn how Lyme disease is diagnosed based on symptoms, physical findings, and laboratory testing. Find out which tests are recommended, how to use them correctly, and what they can and cannot detect.

  6. Serology is the most accurate testing method for Lyme disease, despite false negatives that can occur with acute illness. Antibody testing is universally recommended over polymerase chain...

  7. Learn how to recognize the signs and symptoms of Lyme disease, including the erythema migrans rash, and the challenges of blood tests. Find out about the current problems and limitations of Lyme disease diagnosis and treatment.

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