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1. • • To facilitate the adhesion, white blood cells migrate toward the vessel walls in blood flow through a process called margination. The margination of white cells depends on a number of conditions including local hematocrit, flow rate, red blood cell aggregation, and the deformability of both red and white cells.
     pubmed.ncbi.nlm.nih.gov › 24695813

     White blood cell margination in microcirculation - PubMed

2. People also ask

   Does vessel geometry affect the margination of stiffened red blood cells?

   • Scientific Reports 7, Article number: 15253 ( 2017 ) Cite this article Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the crucial role of the vessel geometry in the margination by calculations when the blood is seen as viscoelastic fluid.

   Margination of Stiffened Red Blood Cells Regulated By Vessel ... - N…

   www.nature.com/articles/s41598-017-15524-0

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   What is the hematocrit of white blood cell margination?

   • Efficient white blood cell margination is found in an intermediate range of hematocrit values of Ht ≈ 0.2-0.4 and at relatively low flow rates, characteristic of the venular part of microcirculation. In addition, aggregation interactions between red blood cells lead to enhanced white-blood-cell margination.

   White blood cell margination in microcirculation - PubMed

   pubmed.ncbi.nlm.nih.gov/24695813/

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   Do tumor cells have a similar margination and adhesion?

   • Some other types of cells, such as platelets [ 15 – 19] and malaria-infected RBCs [ 20, 21 ], have been found to have similar margination in the vessel. So far, there are few quantitative studies on the margination and adhesion of tumor cells.

   Margination and adhesion dynamics of tumor cells in a real ... - PLOS

   journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008746

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   Does vessel cross section affect cell margination?

   • The structure of vessel, such as the curvature and the bifurcation have been proved to be crucial to the cell margination 11, 16, 17. But the cross section of the channel is usually rectangular or circular, the effect of the vessel cross section on cell margination has not been reported yet.

   Margination of Stiffened Red Blood Cells Regulated By Vessel ... - N…

   www.nature.com/articles/s41598-017-15524-0

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3. www.ncbi.nlm.nih.gov › pmc › articlesMonocytes, macrophages, dendritic cells and neutrophils: an...

   www.ncbi.nlm.nih.gov › pmc › articles

   Mar 15, 2021 · The generation of these cells in the bone marrow, to the blood and finally into tissues is a tightly regulated process. Ensuring the adequate production of these cells and their timely removal is key for both the initiation and resolution of inflammation.

   • Figure - PMC - National Center for Biotechnology Information

     Once within the circulation, these cells mature into...

   • White blood cell margination in microcirculation - PubMed

     To facilitate the adhesion, white blood cells migrate toward...

   • Marginating transitional B cells modulate neutrophils in the ...

     Marginating transitional B cells modulate neutrophils in the...

4. www.ncbi.nlm.nih.gov › pmc › articlesBone Marrow, Blood Cells, and the Lymphoid/Lymphatic System

   www.ncbi.nlm.nih.gov › pmc › articles

   Feb 17, 2017 · Circulating cells are free flowing in blood, whereas marginating cells are temporarily adhered to endothelial cells by selectins. In most healthy mammals there are typically equal numbers of neutrophils in the circulating and marginal pools.

   • Author: Katie M. Boes, Amy C. Durham
   • DOI: 10.1016/B978-0-323-35775-3.00013-8

   • Publish Year: 2017
   • Published: 2017

5. www.nature.com › articles › s41598/017/15524-0Margination of Stiffened Red Blood Cells Regulated By Vessel ...

   www.nature.com › articles › s41598/017/15524-0

   Nov 10, 2017 · 16 Citations. Metrics. Margination of stiffened red blood cells has been implicated in many vascular diseases. Here, we report the margination of stiffened RBCs in vivo, and reveal the...

   • Author: Yuanyuan Chen, Donghai Li, Yongjian Li, Jiandi Wan, Jiang Li, Haosheng Chen

   • Publish Year: 2017

6. journals.plos.org › ploscompbiol › articleMargination and adhesion dynamics of tumor cells in a real ...

   journals.plos.org › ploscompbiol › article

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   Feb 19, 2021 · Intuitively, the tumor metastasis starts from a tumor cell migrating towards the vessel wall (namely margination), then adhering to the vessel wall (namely adhesion), and finally extravasating from where it adheres onto. Hence, it is important to investigate the margination and adhesion of tumor cells for understanding the tumor metastasis.

   • Author: Sitong Wang, Ting Ye, Guansheng Li, Xuejiao Zhang, Huixin Shi

   • Publish Year: 2021

7. pubmed.ncbi.nlm.nih.gov › 34313733Marginating transitional B cells modulate neutrophils in the ...

   pubmed.ncbi.nlm.nih.gov › 34313733

   Sep 6, 2021 · Lung intravital confocal microscopy revealed that T2B cells marginate in the pulmonary capillaries via CD49e and require CXCL13 and CXCR5. During lung inflammation, marginated T2B cells dampened excessive neutrophil vascular inflammation via the specialized proresolving molecule lipoxin A4 (LXA4).

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