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1. www.sciencedirect.com › mast-cell-degranulationMast Cell Degranulation - an overview | ScienceDirect Topics

   www.sciencedirect.com › mast-cell-degranulation

   Mast cell degranulation is a central event in the development of the lesions in urticaria, and histamine levels are elevated in biopsied skin. Of note, however, the connective tissue mast cell number in patients with CU (chymase- and tryptase-positive mast cells) is not increased in either lesional or non-lesional skin in comparison with the ...

   • Allergen

     ALLERGENS. E.N.C. Mills, A.S. Tatham, in Encyclopedia of...

   • Mast Cell Degranulation

     Mast Cell Degranulation. Mast cell degranulation is...

2. www.ncbi.nlm.nih.gov › pmc › articlesMast Cell: A Multi-Functional Master Cell - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   Jan 6, 2016 · Mast Cell: A Multi-Functional Master Cell. Mast cells are immune cells of the myeloid lineage and are present in connective tissues throughout the body. The activation and degranulation of mast cells significantly modulates many aspects of physiological and pathological conditions in various settings.

   • Author: Melissa Krystel-Whittemore, Kottarappat N. Dileepan, John G. Wood
   • DOI: 10.3389/fimmu.2015.00620

   • Publish Year: 2016
   • Publication: Front Immunol. 2015; 6: 620.

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     Mast Cells | What is the role of mast cells in inflammation? | Mast cell in allergy | Immunology

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     Mast Cell Degranulation Assessment From Microplate Assay

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     Mast Cells | Normal Role, Allergies, Anaphylaxis, MCAS & Mastocytosis.

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4. www.ncbi.nlm.nih.gov › pmc › articlesRecent advances in our understanding of mast cell activation ...

   www.ncbi.nlm.nih.gov › pmc › articles

   Upon stimulation, mast cells secrete preformed mediators (Table 5) such as β-hexosaminidase (β-hex), histamine, tumor necrosis factor (TNF), and tryptase through rapid (1–5 min) degranulation. Mast cells are the only cell type that stores preformed TNF , which is rapidly secreted and influences T cell recruitment and activation [33–35].

   • Author: Theoharis C Theoharides, Irene Tsilioni, Huali Ren
   • DOI: 10.1080/1744666X.2019.1596800

   • Publish Year: 2019
   • Published: 2019/06

5. www.nature.com › articles › s41577/021/00622-yUnderstanding human mast cells: lesson from therapies for ...

   www.nature.com › articles › s41577/021/00622-y

   Oct 5, 2021 · Also, both species show IgE-mediated mast cell degranulation, and type I hypersensitivity reactions triggered by mast cells are similar in mice and humans. However, specific differences exist.

   • Author: Pavel Kolkhir, Pavel Kolkhir, Pavel Kolkhir, Daniel Elieh-Ali-Komi, Martin Metz, Martin Metz, Frank ...

   • Publish Year: 2021

6. www.ncbi.nlm.nih.gov › pmc › articlesMast Cell Biology: Introduction and Overview - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   As described elsewhere in this overview, KIT is an essential growth and anti-apoptotic factor for the generation of mast cells from progenitors and for the subsequent survival of mature, tissue-resident mast cells. SCF-dependent KIT activation, however, also enhances antigen-mediated mast cell degranulation and cytokine production.

7. www.nature.com › articles › s41590/024/01788-yAnaphylactic degranulation by mast cells requires the ...

   www.nature.com › articles › s41590/024/01788-y

   Mar 14, 2024 · Inflammasome components mediate MC degranulation. Because single-cell transcriptomic analysis reported that Nlrp3 and Asc, but not Caspase-1 mRNA, were constitutively expressed in mouse MCs at the ...

   • Author: Andrea Mencarelli

8. People also ask

   What happens when mast cells are activated and degranulated?

   • When mature mast cells are activated and degranulated, more mast cell progenitors are recruited to the site of inflammation ( ). There are two phenotypes of human mast cells: mucosal mast cells that produce only tryptase and connective tissue mast cells that produce chymase, tryptase, and carboxypeptidases (, ).

   Mast Cell: A Multi-Functional Master Cell - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4701915/

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   What causes granule degranulation in mast cells?

   • When several of these IgE molecules are engaged by allergen, the FcεRs are effectively cross-linked and trigger the degranulation of the mast cell. The symptoms induced by the release of granule contents depend on the localization of the mast cells and the particular effects the mediators have on the local tissues.

   Mast Cell Degranulation - an overview | ScienceDirect Topics

   www.sciencedirect.com/topics/medicine-and-dentistry/mast-cell-degranulation

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   How does mast cell degranulation affect the respiratory system?

   • In the respiratory tract, mast cell degranulation increases vascular permeability and local edema, which can obstruct nasal airways and lead to congestion (, ). There is increased production of mucus and its accumulation can block off the sinuses and result in a bacterial infection.

   Mast Cell: A Multi-Functional Master Cell - PMC - National Center for

   www.ncbi.nlm.nih.gov/pmc/articles/PMC4701915/

   See all results for this question

9. www.sciencedirect.com › mast-cell-degranulationMast Cell Degranulation - an overview | ScienceDirect Topics

   www.sciencedirect.com › mast-cell-degranulation

   Mast Cell Degranulation. Mast cell degranulation is triggered upon binding of the cognate antigen to the IgE-primed mast cell and leads to the release of mediators, such as histamine, tryptase, and serotonin, as well as cytokines, chemokines, and lipid mediators, resulting in acute allergic symptoms. From: Current Opinion in Pharmacology, 2022