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Dec 12, 2022 · There are two main forms of myotonic dystrophy: Myotonic dystrophy type 1 (DM1), also known as Steinert disease. DM1 has four types: classic, mild, congenital and childhood. Myotonic dystrophy type 2 (DM2), also known as proximal myotonic myopathy. Their symptoms overlap, but DM2 tends to be milder than DM1.
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Dec 1, 2020 · Myotonic dystrophy type 2 typically presents in adulthood and has variable manifestations such as early onset cataracts (less than 50 years of age), various grip myotonias, thigh muscle stiffness, muscle pain, and weakness (in hip flexors, hip extensors, or long flexors of the fingers) 4-6,14,64-67. These complaints often appear between 20 and ...
Type 2 DM (DM2), recognized in 1994 as a milder version of DM1, is caused by an abnormally expanded section in a gene on chromosome 3 called ZNF9. DM2 was originally called PROMM, for proximal myotonic myopathy, a term that has remained in use but is somewhat less common than the term DM2.
Sep 21, 2006 · Myotonic dystrophy type 2 (DM2) is characterized by myotonia and muscle dysfunction (proximal and axial weakness, myalgia, and stiffness), and less commonly by posterior subcapsular cataracts, cardiac conduction defects, insulin-insensitive type 2 diabetes mellitus, and other endocrine abnormalities.
Adult-Onset DM1 and DM2. The classic form of DM1 becomes symptomatic between the second and fourth decades of life. In these patients, average lifespan is reduced. Patients diagnosed with DM1 have multiple sets of DNA bases repeats in their genome (known as the CTG repeats).
Mar 15, 2024 · Myotonic dystrophy type 1 (DM1) and myotonic dystrophy type 2 (DM2) are autosomal dominant, multisystem disorders characterized by skeletal muscle weakness and myotonia, cardiac conduction abnormalities, iridescent cataracts, and other abnormalities.
Myotonic muscular dystrophy is a common multi-system disorder that affects the skeletal muscles (the muscles that move the limbs and trunk) as well as smooth muscles (the muscles that control the digestive system) and cardiac muscles of the heart.
It is a genetic disorder characterized by progressive muscle loss and weakness. DM causes weakness of the voluntary muscles, although the degree of weakness and the muscles most affected vary greatly according to the type of DM and the age of the person with the disorder.
Jun 21, 2015 · Myotonic dystrophy type 2, also known as proximal myotonic myopathy (PROMM), is a milder form of myotonic dystrophy in which transient muscle pain is the most common complaint. Only adult-onset forms of DM2 have been recognized.
Jun 21, 2024 · Through this inherited genetic anomaly, individuals living with myotonic dystrophy type 2 can experience varied and complex symptoms, including: Pain. Skeletal muscle problems. Muscle weakness and cramping. Heart complications. Breathing difficulties.
