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This study aimed to investigate whether nitrate use increased the risk of cardiovascular events in patients with HFpEF. The present study is not a prespecified secondary analysis of the Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial data.
Apr 1, 2022 · Therefore, a large proportion of the US population can be categorized as being at-risk for HF or stage A HF. The common causes of HF include ischemic heart disease and myocardial infarction (MI), hypertension, and valvular heart disease (VHD).
May 17, 2011 · In the setting of coronary artery disease, nitrate tolerance has been demonstrated as the loss of effects on treadmill walking time and time of onset of angina.
Apr 4, 2017 · Nitrates may be beneficial in heart failure with preserved ejection fraction (HFpEF) by enhancing cGMP signaling and improving hemodynamics, but real-world data on potential efficacy are lacking.
- Shir Lynn Lim, Lina Benson, Ulf Dahlström, Carolyn S.P. Lam, Lars H. Lund
- 2017
www.uptodate.com · contents · nitrates-in-theNitrates in the management of chronic coronary syndrome
Oct 17, 2023 · In patients with exertional stable angina, nitrates improve exercise tolerance, time to onset of angina, and ST-segment depression during exercise testing. In combination with beta blockers or calcium channel blockers, nitrates produce greater antianginal and antiischemic effects.
www.ncbi.nlm.nih.gov · pmc · articlesNitrates as an Integral Part of Optimal Medical Therapy and ...
Apr 23, 2012 · Tolerance and cross‐tolerance with nitrates are known to occur, and tolerance may develop quickly—usually within 12–24 hours—therefore, a nitrate‐free period of 10–12 hours per day or a low nitrate level at night is generally recommended.
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Are nitrates good for angina?
Does nitrate use affect cardiovascular events in patients with HFpEF?
Are nitrates effective in heart failure with preserved ejection fraction (HFpEF)?
Does nitrate affect activity tolerance in heart failure?
Exogenous nitrate therapy has beneficial effects for HF treatment at the cellular and hemodynamic level by enhancing endothelium dependent vasodilation and improving systolic function and exercise capacity and inhibiting cardiac remodeling in black and non-black HF patients (8,12,13,17–19).
